| Literature DB >> 11714224 |
K Ichikawa1, H Hirai, M Ishiguro, T Kambara, Y Kato, Y J Kim, Y Kojima, Y Matsunaga, H Nishida, Y Shiomi, N Yoshikawa, L H Huang, N Kojima.
Abstract
A series of diterpenes were isolated from the fermentation broth of a fungus, Oidiodendron griseum CL37215. The diterpenes were identified as LL-Z1271alpha, LL-Z1271gamma, CJ-14,445, PR 1388, CJ-14,604 and a new diterpene, CJ-14,515. They inhibited both lipopolysaccharide-induced interleukin-1beta and tumor necrosis factor-alpha production in human whole blood with IC50s of the range from 0.049 to 100 microM.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11714224 DOI： 10.7164/antibiotics.54.697
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649