OBJECTIVE: To study the associations between the intake of flavonols and flavones and the risk of cancer. METHODS: The study cohort consisted of 27,110 male smokers, aged 50-69 years, without history of cancer. They were participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study in Finland. The men completed a validated dietary questionnaire at baseline. Incident cases of cancers were identified through national registers. During an average 6.1-year follow-up, 791 lung cancers, 226 prostate cancers, 156 urothelial cancers, 133 colorectal cancers, 111 stomach cancers, and 92 renal cell cancers were diagnosed. RESULTS: Intake of flavonols and flavones was inversely associated with the risk of lung cancer; multivariate relative risk in the highest vs. the lowest quartile 0.56, 95% confidence interval 0.45-0.69, p for trend 0.0001. The risk was similar in all histological types of lung cancer. No association was found between flavonol and flavone intake and the risk of other cancers. CONCLUSIONS: Intake of flavonols and flavones seemed to be inversely associated with the risk of lung cancer, but not with that of other cancers.
OBJECTIVE: To study the associations between the intake of flavonols and flavones and the risk of cancer. METHODS: The study cohort consisted of 27,110 male smokers, aged 50-69 years, without history of cancer. They were participants of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study in Finland. The men completed a validated dietary questionnaire at baseline. Incident cases of cancers were identified through national registers. During an average 6.1-year follow-up, 791 lung cancers, 226 prostate cancers, 156 urothelial cancers, 133 colorectal cancers, 111 stomach cancers, and 92 renal cell cancers were diagnosed. RESULTS: Intake of flavonols and flavones was inversely associated with the risk of lung cancer; multivariate relative risk in the highest vs. the lowest quartile 0.56, 95% confidence interval 0.45-0.69, p for trend 0.0001. The risk was similar in all histological types of lung cancer. No association was found between flavonol and flavone intake and the risk of other cancers. CONCLUSIONS: Intake of flavonols and flavones seemed to be inversely associated with the risk of lung cancer, but not with that of other cancers.
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Authors: F L Büchner; H B Bueno-de-Mesquita; J Linseisen; H C Boshuizen; L A L M Kiemeney; M M Ros; K Overvad; L Hansen; A Tjonneland; O Raaschou-Nielsen; F Clavel-Chapelon; M-C Boutron-Ruault; M Touillaud; R Kaaks; S Rohrmann; H Boeing; U Nöthlings; A Trichopoulou; D Zylis; V Dilis; D Palli; S Sieri; P Vineis; R Tumino; S Panico; P H M Peeters; C H van Gils; E Lund; I T Gram; T Braaten; C Martinez; A Agudo; L Arriola; E Ardanaz; C Navarro; L Rodríguez; J Manjer; E Wirfält; G Hallmans; T Rasmuson; T J Key; A W Roddam; S Bingham; K-T Khaw; N Slimani; P Bofetta; G Byrnes; T Norat; D Michaud; E Riboli Journal: Cancer Causes Control Date: 2010-03 Impact factor: 2.506