Literature DB >> 11713575

Dynamics of structural and functional changes in hepatocyte mitochondria of senescence-accelerated OXYS rats.

N G Kolosova1, S V Aidagulova, G I Nepomnyashchikh, I G Shabalina, N I Shalbueva.   

Abstract

Electron microscopy showed signs of degenerative dystrophic changes in hepatocytes and structural decompensation of mitochondria in senescence-accelerated OXYS rats in comparison with Wistar rats. These signs were detected in the presence of liver mitochondria dysfunction in OXYS rats: reduced oxygen consumption rate in all metabolic states, respiratory control volume, ADP/O ratio. transmembrane potential, and phosphorylation rate. The revealed disorders in mitochondrial structure and function are the key factors in the pathogenesis of accelerated aging in OXYS rats and visceropathies characteristic of these animals.

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Year:  2001        PMID： 11713575     DOI： 10.1023/a:1013014919721

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  8 in total

1.  Rat retinal transcriptome: effects of aging and AMD-like retinopathy.

Authors:  Oyuna S Kozhevnikova; Elena E Korbolina; Nikita I Ershov; Natalia G Kolosova
Journal:  Cell Cycle       Date:  2013-05-06       Impact factor: 4.534

Review 2.  Saturated fatty acid metabolism is key link between cell division, cancer, and senescence in cellular and whole organism aging.

Authors:  Judith H Ford
Journal:  Age (Dordr)       Date:  2010-01-14

Review 3.  Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease.

Authors:  Natalia A Stefanova; Oyuna S Kozhevnikova; Anton O Vitovtov; Kseniya Yi Maksimova; Sergey V Logvinov; Ekaterina A Rudnitskaya; Elena E Korbolina; Natalia A Muraleva; Nataliya G Kolosova
Journal:  Cell Cycle       Date:  2014-02-17       Impact factor: 4.534

4.  The mitochondria-targeted antioxidant SkQ1 restores αB-crystallin expression and protects against AMD-like retinopathy in OXYS rats.

Authors:  Natalia A Muraleva; Oyuna S Kozhevnikova; Anna A Zhdankina; Natalia A Stefanova; Tatyana V Karamysheva; Anzhella Z Fursova; Nataliya G Kolosova
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

5.  Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats.

Authors:  Lidia A Obukhova; Vladimir P Skulachev; Natalia G Kolosova
Journal:  Aging (Albany NY)       Date:  2009-04-22       Impact factor: 5.682

6.  Therapeutic action of the mitochondria-targeted antioxidant SkQ1 on retinopathy in OXYS rats linked with improvement of VEGF and PEDF gene expression.

Authors:  Anton M Markovets; Anzhella Z Fursova; Natalia G Kolosova
Journal:  PLoS One       Date:  2011-07-05       Impact factor: 3.240

7.  Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats.

Authors:  Natalia A Stefanova; Natalia A Muraleva; Elena E Korbolina; Elena Kiseleva; Kseniya Yi Maksimova; Nataliya G Kolosova
Journal:  Oncotarget       Date:  2015-01-30

8.  An antioxidant specifically targeting mitochondria delays progression of Alzheimer's disease-like pathology.

Authors:  Natalia A Stefanova; Natalia A Muraleva; Kseniya Yi Maksimova; Ekaterina A Rudnitskaya; Elena Kiseleva; Darya V Telegina; Nataliya G Kolosova
Journal:  Aging (Albany NY)       Date:  2016-10-06       Impact factor: 5.682
  8 in total

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