Literature DB >> 11713190

Characteristics of post-transcriptional gene silencing.

A Chicas1, G Macino.   

Abstract

A number of gene silencing phenomena that inactivate genes at the post-transcriptional level have been identified. Due to its potential for studying gene function, post-transcriptional gene silencing (PTGS) has become an intense area of research. In this review we describe the different means of inducing PTGS and discuss the possible biological roles of these artificially induced phenomena. We also discuss other features of PTGS such as the mechanism of mRNA degradation, the nature of the silencing signal and the mechanism of PTGS inhibition by viral proteins.

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Year:  2001        PMID： 11713190      PMCID： PMC1084130          DOI： 10.1093/embo-reports/kve231

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  51 in total

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2.  An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells.

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Review 3.  Post-transcriptional gene silencing across kingdoms.

Authors:  C Cogoni; G Macino
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Review 4.  Gene silencing as an adaptive defence against viruses.

Authors:  P M Waterhouse; M B Wang; T Lough
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5.  A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA.

Authors:  G Hutvágner; J McLachlan; A E Pasquinelli; E Bálint; T Tuschl; P D Zamore
Journal:  Science       Date:  2001-07-12       Impact factor: 47.728

6.  A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans.

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7.  EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans.

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Journal:  Curr Biol       Date:  2000-02-24       Impact factor: 10.834

8.  Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing.

Authors:  A Grishok; A E Pasquinelli; D Conte; N Li; S Parrish; I Ha; D L Baillie; A Fire; G Ruvkun; C C Mello
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9.  DNA methylation and chromatin structure affect transcriptional and post-transcriptional transgene silencing in Arabidopsis.

Authors:  J B Morel; P Mourrain; C Béclin; H Vaucheret
Journal:  Curr Biol       Date:  2000 Dec 14-28       Impact factor: 10.834

10.  Stochastic and nonstochastic post-transcriptional silencing of chitinase and beta-1,3-glucanase genes involves increased RNA turnover-possible role for ribosome-independent RNA degradation.

Authors:  H Holtorf; H Schöb; C Kunz; R Waldvogel; F Meins
Journal:  Plant Cell       Date:  1999-03       Impact factor: 11.277
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  16 in total

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2.  High molecular weight RNAs and small interfering RNAs induce systemic posttranscriptional gene silencing in plants.

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Journal:  Naturwissenschaften       Date:  2003-07-23

4.  The presence of a chromatin boundary appears to shield a transgene in tobacco from RNA silencing.

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5.  Hypovirus papain-like protease p29 suppresses RNA silencing in the natural fungal host and in a heterologous plant system.

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Journal:  Eukaryot Cell       Date:  2006-06

6.  Heterologous virus-induced gene silencing as a promising approach in plant functional genomics.

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7.  Transient expression of human serum albumin (HSA) in tobacco leaves.

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8.  Small interfering RNAs that trigger posttranscriptional gene silencing are not required for the histone H3 Lys9 methylation necessary for transgenic tandem repeat stabilization in Neurospora crassa.

Authors:  Agustin Chicas; Emma C Forrest; Silvia Sepich; Carlo Cogoni; Giuseppe Macino
Journal:  Mol Cell Biol       Date:  2005-05       Impact factor: 4.272

9.  Long-distance movement, virulence, and RNA silencing suppression controlled by a single protein in hordei- and potyviruses: complementary functions between virus families.

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Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

10.  Two classes of small antisense RNAs in fungal RNA silencing triggered by non-integrative transgenes.

Authors:  Francisco E Nicolás; Santiago Torres-Martínez; Rosa M Ruiz-Vázquez
Journal:  EMBO J       Date:  2003-08-01       Impact factor: 11.598
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