Literature DB >> 11712748

The role of epidermal growth factor in mucus production.

J A Nadel1, P R Burgel.   

Abstract

Airway hypersecretion is a serious and presently untreatable symptom of chronic inflammatory airway diseases. Recently, it has been discovered that epithelial growth factor receptor expression and activation causes mucin production in airways. An epithelial growth factor receptor pathway is implicated in mucus cell differentiation induced by various stimuli; therefore, inhibition of the epithelial growth factor receptor transduction cascade may provide effective new treatments for hypersecretory airway diseases.

Mesh：

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Year:  2001        PMID： 11712748     DOI： 10.1016/s1471-4892(01)00045-5

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  12 in total

1.  The Epithelial Cell in Lung Health and Emphysema Pathogenesis.

Authors:  Becky A Mercer; Vincent Lemaître; Charles A Powell; Jeanine D'Armiento
Journal:  Curr Respir Med Rev       Date:  2006-05

2.  IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease.

Authors:  Charlotte Mitchell; Karin Provost; Naiqian Niu; Robert Homer; Lauren Cohn
Journal:  J Immunol       Date:  2011-08-26       Impact factor: 5.422

3.  Arylhydrocarbon receptor activation in NCI-H441 cells and C57BL/6 mice: possible mechanisms for lung dysfunction.

Authors:  Patrick S Wong; Chris F Vogel; Katherine Kokosinski; Fumio Matsumura
Journal:  Am J Respir Cell Mol Biol       Date:  2009-04-16       Impact factor: 6.914

4.  SPDEF regulates goblet cell hyperplasia in the airway epithelium.

Authors:  Kwon-Sik Park; Thomas R Korfhagen; Michael D Bruno; Joseph A Kitzmiller; Huajing Wan; Susan E Wert; Gurjit K Khurana Hershey; Gang Chen; Jeffrey A Whitsett
Journal:  J Clin Invest       Date:  2007-03-08       Impact factor: 14.808

Review 5.  The Role of Guaifenesin in the Management of Chronic Mucus Hypersecretion Associated with Stable Chronic Bronchitis: A Comprehensive Review.

Authors:  Jill A Ohar; James F Donohue; Selwyn Spangenthal
Journal:  Chronic Obstr Pulm Dis       Date:  2019-10-23

6.  Effects of second hand smoke on airway secretion and mucociliary clearance.

Authors:  Yanyan Liu; Y Peter Di
Journal:  Front Physiol       Date:  2012-08-28       Impact factor: 4.566

Review 7.  Airway hypersecretion in allergic rhinitis and asthma: new pharmacotherapy.

Authors:  Duncan F Rogers
Journal:  Curr Allergy Asthma Rep       Date:  2003-05       Impact factor: 4.919

8.  Smoking cessation and bronchial epithelial remodelling in COPD: a cross-sectional study.

Authors:  Thérèse S Lapperre; Jacob K Sont; Annemarie van Schadewijk; Margot Me Gosman; Dirkje S Postma; Ingeborg M Bajema; Wim Timens; Thais Mauad; Pieter S Hiemstra
Journal:  Respir Res       Date:  2007-11-26

9.  MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation.

Authors:  Magdalena M Gorska; Qiaoling Liang; Susan J Stafford; Nicolas Goplen; Nilesh Dharajiya; Lei Guo; Sanjiv Sur; Matthias Gaestel; Rafeul Alam
Journal:  J Exp Med       Date:  2007-06-25       Impact factor: 14.307

10.  Inverse association of plasma IL-13 and inflammatory chemokines with lung function impairment in stable COPD: a cross-sectional cohort study.

Authors:  Janet S Lee; Matthew R Rosengart; Venkateswarlu Kondragunta; Yingze Zhang; Jessica McMurray; Robert A Branch; Augustine M K Choi; Frank C Sciurba
Journal:  Respir Res       Date:  2007-09-14
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