Literature DB >> 11712672

Ursolic acid: an anti-tumorigenic and chemopreventive activity. Minireview.

L Novotný1, A Vachálková, D Biggs.   

Abstract

Ursolic acid, UA, as a pentacyclic triterpene is of interest to scientists in the area of oncology because of its cytotoxicity, induction of differentiation, anti-mutagenic, antiviral and anti-invasive activities. UA is capable of inducing apoptosis in tumor cells on one side and to prevent malignant transformation of normal cells on the other side. It also interferes with numerous enzymes, including the ones serving directly to DNA synthesis. The aim of this review is to summarize reports on UA biological properties and to show its main anti-tumor effects and chemopreventive properties in normal cells.

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Year:  2001        PMID： 11712672

Source DB:  PubMed          Journal:  Neoplasma        ISSN： 0028-2685            Impact factor:   2.575


  16 in total

1.  Pharmacophore, QSAR, and ADME based semisynthesis and in vitro evaluation of ursolic acid analogs for anticancer activity.

Authors:  Komal Kalani; Dharmendra Kumar Yadav; Feroz Khan; Santosh K Srivastava; Nitasha Suri
Journal:  J Mol Model       Date:  2012-01-21       Impact factor: 1.810

2.  Comparison of Neuroprotective Effects of Melissa officinalis Total Extract and Its Acidic and Non-Acidic Fractions against A β-Induced Toxicity.

Authors:  Mohammad Reza Sepand; Maliheh Soodi; Homa Hajimehdipoor; Masoud Soleimani; Ehsan Sahraei
Journal:  Iran J Pharm Res       Date:  2013       Impact factor: 1.696

Review 3.  Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene.

Authors:  Mohammad Saleem
Journal:  Cancer Lett       Date:  2009-05-22       Impact factor: 8.679

4.  In Silico Docking to Explicate Interface between Plant-Originated Inhibitors and E6 Oncogenic Protein of Highly Threatening Human Papillomavirus 18.

Authors:  Satish Kumar; Lingaraja Jena; Maheswata Sahoo; Mrunmayi Kakde; Sangeeta Daf; Ashok K Varma
Journal:  Genomics Inform       Date:  2015-06-30

5.  Cytotoxicity, antimicrobial and antioxidant activity of eight compounds isolated from Entada abyssinica (Fabaceae).

Authors:  Jean P Dzoyem; Raduis Melong; Armelle T Tsamo; Alembert T Tchinda; Deccaux G W F Kapche; Bonaventure T Ngadjui; Lyndy J McGaw; Jacobus N Eloff
Journal:  BMC Res Notes       Date:  2017-03-06

6.  Effects of ursolic acid on sub-lesional muscle pathology in a contusion model of spinal cord injury.

Authors:  Gregory E Bigford; Andrew J Darr; Valerie C Bracchi-Ricard; Han Gao; Mark S Nash; John R Bethea
Journal:  PLoS One       Date:  2018-08-29       Impact factor: 3.240

7.  A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors.

Authors:  Zhongling Zhu; Zhengzi Qian; Zhao Yan; Cuicui Zhao; Huaqing Wang; Guoguang Ying
Journal:  Int J Nanomedicine       Date:  2013-01-04

8.  Ursolic acid, a naturally occurring triterpenoid, demonstrates anticancer activity on human prostate cancer cells.

Authors:  E Kassi; Z Papoutsi; H Pratsinis; N Aligiannis; M Manoussakis; P Moutsatsou
Journal:  J Cancer Res Clin Oncol       Date:  2007-02-15       Impact factor: 4.322

9.  Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats.

Authors:  David Andersson; Yajun Cheng; Rui-Dong Duan
Journal:  J Cancer Res Clin Oncol       Date:  2007-06-29       Impact factor: 4.322

10.  Comparative Study of Green Sub- and Supercritical Processes to Obtain Carnosic Acid and Carnosol-Enriched Rosemary Extracts with in Vitro Anti-Proliferative Activity on Colon Cancer Cells.

Authors:  Andrea Del Pilar Sánchez-Camargo; Virginia García-Cañas; Miguel Herrero; Alejandro Cifuentes; Elena Ibáñez
Journal:  Int J Mol Sci       Date:  2016-12-07       Impact factor: 5.923
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