| Literature DB >> 11711296 |
K J Hodgetts1, A Kieltyka, R Brodbeck, J N Tran, J W Wasley, A Thurkauf.
Abstract
A series of novel 6-(4-benzylpiperazin-1-yl)benzodioxanes were prepared and screened at selected dopamine receptor subtypes. 6-(4-[4-Chlorobenzyl]piperazin-1-yl)benzodioxane (2d) had high affinity and selectivity for the D(4) dopamine receptor subtype and was identified as a D(4) antagonist via its attenuation of dopamine-induced GTPgamma(35)S binding at the D(4) receptor.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11711296 DOI： 10.1016/s0968-0896(01)00226-7
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641