Literature DB >> 11711289

Studies on alpha(1-->5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity.

A K Pathak1, V Pathak, J A Maddry, W J Suling, S S Gurcha, G S Besra, R C Reynolds.   

Abstract

The appearance multi-drug resistant Mycobacterium tuberculosis (MTB) throughout the world has prompted a search for new, safer and more active agents against tuberculosis. Based on studies of the biosynthesis of mycobacterial cell wall polysaccharides, octyl 5-O-(alpha-D-arabinofuranosyl)-alpha-D-arabinofuranoside analogues were synthesized and evaluated as inhibitors for M. tuberculosis and Mycobacterium avium. A cell free assay system has been used for the evaluation of these disaccharides as substrates for mycobacterial arabinosyltransferase activity.

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Year:  2001        PMID： 11711289     DOI： 10.1016/s0968-0896(01)00180-8

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

Review 1.  Targeting the formation of the cell wall core of M. tuberculosis.

Authors:  Clifton E Barry; Dean C Crick; Michael R McNeil
Journal:  Infect Disord Drug Targets       Date:  2007-06

2.  Synthesis of deoxygenated alpha(1-->5)-linked arabinofuranose disaccharides as substrates and inhibitors of arabinosyltransferases of Mycobacterium tuberculosis.

Authors:  Ashish K Pathak; Vibha Pathak; William J Suling; James R Riordan; Sudagar S Gurcha; Gurdyal S Besra; Robert C Reynolds
Journal:  Bioorg Med Chem       Date:  2008-11-18       Impact factor: 3.641

3.  Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis.

Authors:  Ashish K Pathak; Vibha Pathak; James R Riordan; William J Suling; Sudagar S Gurcha; Gurdyal S Besra; Robert C Reynolds
Journal:  Bioorg Med Chem Lett       Date:  2007-06-06       Impact factor: 2.823

4.  Disaccharide analogs as probes for glycosyltransferases in Mycobacterium tuberculosis.

Authors:  Ashish K Pathak; Vibha Pathak; Lainne Seitz; Sudagar S Gurcha; Gurdyal S Besra; James M Riordan; Robert C Reynolds
Journal:  Bioorg Med Chem       Date:  2007-04-10       Impact factor: 3.641
  4 in total

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