Literature DB >> 117099

Possible mechanism of the inhibitory effect of ouabain on renin secretion from rat renal cortical slices.

P C Churchill.   

Abstract

1. The effects of ouabain on renin secretion by rat renal cortical slices were studied. 2. Renin secretion was inhibited by 10(-3) M-ouabain in the presence of free Ca (10(-4) to 2.6 x 10(-3) M). Inhibition was blocked at Ca less than 10(-8) M. 3. The effect of free Ca on ouabain-inhibition was shown to be independent of the presence of EGTA, completely reversible, and unrelated to passive leakage of renin from non-viable cells, as assessed by simultaneous release of lactate dehydrogenase activity (LDH). 4. It is proposed that, as a result of inhibition of Na, K-ATPase by ouabain, (a) intracellular Na increases in the renin-secreting juxtaglomerular cells, (b) intracellular Ca increases, via an Na-Ca exchange mechanism, and (c) that Ca accumulation, in some unknown manner, inhibits renin secretion.

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Year:  1979        PMID： 117099      PMCID： PMC1280546          DOI： 10.1113/jphysiol.1979.sp012919

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


  36 in total

Review 1.  The role of Na+,K+-ATPase in the inotropic action of digitalis.

Authors:  T Akera; T M Brody
Journal:  Pharmacol Rev       Date:  1977-09       Impact factor: 25.468

2.  Characteristics of renin release from isolated superfused glomeruli in vitro.

Authors:  K Blendstrup; P P Leyssac; K Poulsen; S L Skinner
Journal:  J Physiol       Date:  1975-04       Impact factor: 5.182

3.  The effects of ionophores (A23187 and RO2-2985) on renin secretion and renal vasoconstriction.

Authors:  M Fynn; N Onomakpome; W S Peart
Journal:  Proc R Soc Lond B Biol Sci       Date:  1977-11-14

4.  The regulation of cellular volume in renal cortical slices incubated in hyposmotic medium.

Authors:  P M Hughes; D C Macknight
Journal:  J Physiol       Date:  1976-05       Impact factor: 5.182

5.  Renin secretion and distal tubule Na+ in rats.

Authors:  P C Churchill; M C Churchill; F D McDonald
Journal:  Am J Physiol       Date:  1978-12

6.  Calcium in the control of renin release.

Authors:  C S Park; R L Malvin
Journal:  Am J Physiol       Date:  1978-07

7.  Glycerol-induced acute renal failure in the two kidney Goldblatt rat.

Authors:  P Churchill; A Bidani; L Fleischmann; B Becker-McKenna
Journal:  Am J Physiol       Date:  1977-09

8.  Renal function and renin secretion after administration of ouabain and ouabain plus furosemide in conscious sheep.

Authors:  E H Blaine; M B Zimmerman
Journal:  Circ Res       Date:  1978-07       Impact factor: 17.367

9.  Renin secretion as a function of renal renin content in dogs.

Authors:  C S Park; R L Malvin; R D Murray; K W Cho
Journal:  Am J Physiol       Date:  1978-06

10.  Studies on the mechanism of renin release from isolated superfused rat glomeruli: effects of calcium, calcium ionophore and lanthanum.

Authors:  L Baumbach; P P Leyssac
Journal:  J Physiol       Date:  1977-12       Impact factor: 5.182
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  13 in total

1.  Effect of melittin on renin and prostaglandin E2 release from rat renal cortical slices.

Authors:  P C Churchill; N F Rossi; M C Churchill; V R Ellis
Journal:  J Physiol       Date:  1990-09       Impact factor: 5.182

2.  Pressure induces intracellular calcium changes in juxtaglomerular cells in perfused afferent arterioles.

Authors:  En Yin Lai; Yibing Wang; Anders Erik Gosta Persson; Roy Davis Manning; Ruisheng Liu
Journal:  Hypertens Res       Date:  2011-06-02       Impact factor: 3.872

3.  Identification and characterization of a ouabain-like compound from human plasma.

Authors:  J M Hamlyn; M P Blaustein; S Bova; D W DuCharme; D W Harris; F Mandel; W R Mathews; J H Ludens
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

4.  Intracellular control of renin release--an overview.

Authors:  A Kurtz
Journal:  Klin Wochenschr       Date:  1986-09-15

5.  The effect of oral digoxin on sodium excretion, renin-angiotensin-aldosterone system and blood pressure in normotensive subjects.

Authors:  F P Cappuccio; N D Markandu; G A Sagnella; G A MacGregor
Journal:  Postgrad Med J       Date:  1986-04       Impact factor: 2.401

6.  Secretion control for active and inactive renin: effects of calcium and potassium on rabbit kidney cortex slices.

Authors:  L M Ginesi; K A Munday; A R Noble
Journal:  J Physiol       Date:  1983-11       Impact factor: 5.182

7.  XAC, a functionalized congener of 1,3-dialkylxanthine, antagonizes A1 adenosine receptor-mediated inhibition of renin secretion in vitro.

Authors:  P C Churchill; K A Jacobson; M C Churchill
Journal:  Arch Int Pharmacodyn Ther       Date:  1987-12

8.  Inhibitory effect of ouabain on in vitro and in vivo gastric acid secretion in the frog and the rat.

Authors:  E S Assem; B Y Wan
Journal:  Experientia       Date:  1984-08-15

9.  Effect of D-600 on inhibition of in vitro renin release in the rat by high extracellular potassium and angiotensin II.

Authors:  P C Churchill
Journal:  J Physiol       Date:  1980-07       Impact factor: 5.182

10.  Evidence for a raised concentration of a circulating sodium transport inhibitor in essential hypertension.

Authors:  G A MacGregor; S Fenton; J Alaghband-Zadeh; N Markandu; J E Roulston; H E de Wardener
Journal:  Br Med J (Clin Res Ed)       Date:  1981-11-21
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