Literature DB >> 11709359

In vitro activities of a new ketolide, ABT-773, against multidrug-resistant gram-positive cocci.

K V Singh1, K Malathum, B E Murray.   

Abstract

The in vitro activities of ABT-773 were evaluated against 324 strains of gram-positive bacteria, including multidrug-resistant Staphylococcus spp. and Enterococcus spp. ABT-773 had lower MIC ranges, MICs at which 50% of isolates are inhibited (MIC(50)s), and MIC(90)s than erythromycin or clindamycin for almost all isolates tested. The MICs of ABT-773 were also lower than those of quinupristin-dalfopristin (Q-D) for methicillin-susceptible Staphylococcus aureus, Rhodococcus spp., and Streptococcus spp., while the MICs of Q-D were lower than those of ABT-773 for methicillin-resistant S. aureus and Enterococcus faecium, including vancomycin-resistant isolates.

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Year:  2001        PMID： 11709359      PMCID： PMC90888          DOI： 10.1128/AAC.45.12.3640-3643.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

Review 1.  Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants.

Authors:  M C Roberts; J Sutcliffe; P Courvalin; L B Jensen; J Rood; H Seppala
Journal:  Antimicrob Agents Chemother       Date:  1999-12       Impact factor: 5.191

Review 2.  Vancomycin-resistant enterococcal infections.

Authors:  B E Murray
Journal:  N Engl J Med       Date:  2000-03-09       Impact factor: 91.245

Review 3.  Resurgent and emergent disease in a changing world.

Authors:  M L Cohen
Journal:  Br Med Bull       Date:  1998       Impact factor: 4.291

4.  Staphylococcus aureus with reduced susceptibility to vancomycin--United States, 1997.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  1997-08-22       Impact factor: 17.586

5.  In vitro activity of ABT-773, a new ketolide, against recent clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.

Authors:  A B Brueggemann; G V Doern; H K Huynh; E M Wingert; P R Rhomberg
Journal:  Antimicrob Agents Chemother       Date:  2000-02       Impact factor: 5.191

Review 6.  Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification.

Authors:  R Leclercq; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1991-07       Impact factor: 5.191

7.  Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility.

Authors:  K Hiramatsu; H Hanaki; T Ino; K Yabuta; T Oguri; F C Tenover
Journal:  J Antimicrob Chemother       Date:  1997-07       Impact factor: 5.790

Review 8.  Diversity among multidrug-resistant enterococci.

Authors:  B E Murray
Journal:  Emerg Infect Dis       Date:  1998 Jan-Mar       Impact factor: 6.883

Review 9.  Recent progress in novel macrolides, quinolones, and 2-pyridones to overcome bacterial resistance.

Authors:  D T Chu
Journal:  Med Res Rev       Date:  1999-11       Impact factor: 12.944

10.  Detection of erythromycin-resistant determinants by PCR.

Authors:  J Sutcliffe; T Grebe; A Tait-Kamradt; L Wondrack
Journal:  Antimicrob Agents Chemother       Date:  1996-11       Impact factor: 5.191
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  2 in total

Review 1.  The ketolides: a critical review.

Authors:  George G Zhanel; Michael Walters; Ayman Noreddin; Lavern M Vercaigne; Aleksandra Wierzbowski; John M Embil; Alfred S Gin; Stephen Douthwaite; Daryl J Hoban
Journal:  Drugs       Date:  2002       Impact factor: 9.546

2.  In vivo efficacy of the ketolide ABT-773 (cethromycin) against enterococci in a mouse peritonitis model.

Authors:  Suresh R Pai; Kavindra V Singh; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191
  2 in total

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