Literature DB >> 11709350

Pharmacokinetic-pharmacodynamic modeling of electroencephalogram effect of imipenem in rats with acute renal failure.

A Dupuis1, A Limosin, J Paquereau, O Mimoz, W Couet, S Bouquet.   

Abstract

The epileptogenic activity of imipenem was investigated in rats with experimental renal failure induced by uranyl nitrate injection by using electroencephalogram (EEG) recording and a pharmacokinetic-pharmacodynamic model including an effect compartment. Results previously obtained with healthy rats were used to estimate the dose of imipenem required to induce an observable but nonlethal EEG effect on the assumption that only the pharmacokinetic parameters of the model would be affected by renal failure. Good agreement was observed between the predicted and observed effects.

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Year:  2001        PMID： 11709350      PMCID： PMC90879          DOI： 10.1128/AAC.45.12.3607-3609.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of imipenem in healthy rats.

Authors:  A Dupuis; W Couet; J Paquereau; S Debarre; A Portron; C Jamois; S Bouquet
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

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Authors:  G B Calandra; C Wang; M Aziz; K R Brown
Journal:  J Antimicrob Chemother       Date:  1986-12       Impact factor: 5.790

3.  Review of adverse experiences and tolerability in the first 2,516 patients treated with imipenem/cilastatin.

Authors:  G B Calandra; K R Brown; L C Grad; V I Ahonkhai; C Wang; M A Aziz
Journal:  Am J Med       Date:  1985-06-07       Impact factor: 4.965

4.  Pharmacokinetic-pharmacodynamic modeling of the anticonvulsant and electroencephalogram effects of phenytoin in rats.

Authors:  O E Della Paschoa; J W Mandema; R A Voskuyl; M Danhof
Journal:  J Pharmacol Exp Ther       Date:  1998-02       Impact factor: 4.030

5.  Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine.

Authors:  L B Sheiner; D R Stanski; S Vozeh; R D Miller; J Ham
Journal:  Clin Pharmacol Ther       Date:  1979-03       Impact factor: 6.875

Review 6.  Neurotoxicity of beta-lactam antibiotics: predisposing factors and pathogenesis.

Authors:  S E Schliamser; O Cars; S R Norrby
Journal:  J Antimicrob Chemother       Date:  1991-04       Impact factor: 5.790

7.  Factors predisposing to seizures in seriously ill infected patients receiving antibiotics: experience with imipenem/cilastatin.

Authors:  G Calandra; E Lydick; J Carrigan; L Weiss; H Guess
Journal:  Am J Med       Date:  1988-05       Impact factor: 4.965

8.  Kinetics of drug action in disease states. II. Effect of experimental renal dysfunction on phenobarbital concentrations in rats at onset of loss of righting reflect.

Authors:  M Danhof; M Hisaoka; G Levy
Journal:  J Pharmacol Exp Ther       Date:  1984-09       Impact factor: 4.030

9.  Comparative convulsant potencies of two carbapenem derivatives in C57 and DBA/2 mice.

Authors:  A de Sarro; C Imperatore; P Mastroeni; G de Sarro
Journal:  J Pharm Pharmacol       Date:  1995-04       Impact factor: 3.765

10.  Evaluation of methods for producing renal dysfunction in rats.

Authors:  K M Giacomini; S M Roberts; G Levy
Journal:  J Pharm Sci       Date:  1981-02       Impact factor: 3.534
  10 in total
  3 in total

1.  Lack of effect of experimental hypovolemia on imipenem muscle distribution in rats assessed by microdialysis.

Authors:  Sandrine Marchand; Claire Dahyot; Isabelle Lamarche; Elodie Plan; Olivier Mimoz; William Couet
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

2.  Simultaneous determination of 12 beta-lactam antibiotics in human plasma by high-performance liquid chromatography with UV detection: application to therapeutic drug monitoring.

Authors:  Marie-Clémence Verdier; Olivier Tribut; Pierre Tattevin; Yves Le Tulzo; Christian Michelet; Danièle Bentué-Ferrer
Journal:  Antimicrob Agents Chemother       Date:  2011-07-25       Impact factor: 5.191

3.  Microdialysis study of imipenem distribution in skeletal muscle and lung extracellular fluids of noninfected rats.

Authors:  Sandrine Marchand; Claire Dahyot; Isabelle Lamarche; Olivier Mimoz; William Couet
Journal:  Antimicrob Agents Chemother       Date:  2005-06       Impact factor: 5.191
  3 in total

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