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Literature DB >> 11709109

Diacerein as a disease-modulating agent in osteoarthritis.

Abstract

This paper reviews the most recent clinical and experimental studies on diacerein, both of which are under investigation. Diacerein could be a disease-modulating agent in osteoarthritis because structural benefits have been reported in recent trials. Moreover, after an empirical use, studies return to the experimental field to understand the mechanism of action of this molecule. However, clinical trials using new sets of criteria could be conducted to estimate the structural modulating effect of diacerein; experimental studies must be performed to understand this effect.

Entities: Chemical

Mesh：

Substances：

Year: 2001 PMID： 11709109 DOI： 10.1007/s11926-001-0061-y

Source DB: PubMed Journal: Curr Rheumatol Rep ISSN： 1523-3774 Impact factor: 4.686

30 in total

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Journal: Pharmacology Date: 1988 Impact factor: 2.547

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Journal: Rev Rhum Engl Ed Date: 1997-12

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Journal: J Pharm Pharmacol Date: 1988-01 Impact factor: 3.765

4. Efficacy and safety of diacerein in osteoarthritis of the knee: a double-blind, placebo-controlled trial. The Diacerein Study Group.

Authors: J P Pelletier; M Yaron; B Haraoui; P Cohen; M A Nahir; D Choquette; I Wigler; I A Rosner; A D Beaulieu
Journal: Arthritis Rheum Date: 2000-10

5. Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes.

Authors: T Tamura; N Kosaka; J Ishiwa; T Sato; H Nagase; A Ito
Journal: Osteoarthritis Cartilage Date: 2001-04 Impact factor: 6.576

6. [Molecular mechanisms implicated in the inhibition of collagenase expression by diacerheine].

Authors: T F Cruz; J Tang; S Pronost; J P Pujol
Journal: Rev Prat Date: 1996-03-15

7. The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis.

Authors: S Y Hwa; D Burkhardt; C Little; P Ghosh
Journal: J Rheumatol Date: 2001-04 Impact factor: 4.666

8. Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.

Authors: J P Pelletier; D Lajeunesse; P Reboul; F Mineau; J C Fernandes; P Sabouret; J Martel-Pelletier
Journal: J Rheumatol Date: 2001-04 Impact factor: 4.666

9. [Diacetylrhein on a postcontusion model of experimental osteoarthritis in the rabbit].

Authors: B Mazières; L Berdah; M Thiéchart; G Viguier
Journal: Rev Rhum Ed Fr Date: 1993-07

10. Diacerhein in the treatment of osteoarthritis of the hip.

Authors: M Nguyen; M Dougados; L Berdah; B Amor
Journal: Arthritis Rheum Date: 1994-04

1 in total

1. Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal.

Authors: Gellan Alaa Mohamed Kamel; Eman Harahsheh; Shaimaa Hussein
Journal: Mol Biol Rep Date: 2022-04-02 Impact factor: 2.742

1 in total