Literature DB >> 11709098

Genetic analysis of the complete gag and env genes of HIV type 1 subtype C primary isolates from South Africa.

S Engelbrecht1, T de Villiers, C C Sampson, J zur Megede, S W Barnett, E J van Rensburg.   

Abstract

South Africa has one of the fastest growing HIV-1 epidemics, with an estimated 4.7 million people infected. To better understand the genetic diversity of this epidemic and its potential impact on vaccine development, we have cloned and sequenced the complete gag and env genes of 13 primary virus isolates. Phylogenetic analysis of our sequences and 69 complete env genes from the Los Alamos and GenBank databases revealed multiple subclusters within subtype C. The V3 loop region was relatively conserved in all our strains when compared with other subtypes, but the region immediately downstream was highly variable. No intersubtype recombinant forms were observed when comparing the gag and env sequences. Characterization of the complete gag and env genes enabled us to select specific strains for further vaccine development.

Entities:  

Mesh：

Year:  2001        PMID： 11709098     DOI： 10.1089/08892220152644241

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  10 in total

1.  Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern Africa.

Authors:  Ming Li; Jesus F Salazar-Gonzalez; Cynthia A Derdeyn; Lynn Morris; Carolyn Williamson; James E Robinson; Julie M Decker; Yingying Li; Maria G Salazar; Victoria R Polonis; Koleka Mlisana; Salim Abdool Karim; Kunxue Hong; Kelli M Greene; Miroslawa Bilska; Jintao Zhou; Susan Allen; Elwyn Chomba; Joseph Mulenga; Cheswa Vwalika; Feng Gao; Ming Zhang; Bette T M Korber; Eric Hunter; Beatrice H Hahn; David C Montefiori
Journal:  J Virol       Date:  2006-09-13       Impact factor: 5.103

2.  Coreceptor usage, diversity, and divergence in drug-naive and drug-exposed individuals from Malawi, infected with HIV-1 subtype C for more than 20 years.

Authors:  Ishla Seager; Simon A Travers; Michael D Leeson; Amelia C Crampin; Neil French; Judith R Glynn; Grace P McCormack
Journal:  AIDS Res Hum Retroviruses       Date:  2014-07-29       Impact factor: 2.205

3.  Next generation sequencing reveals a high frequency of CXCR4 utilizing viruses in HIV-1 chronically infected drug experienced individuals in South Africa.

Authors:  Nontokozo D Matume; Denis M Tebit; Laurie R Gray; Marie-Louise Hammarskjold; David Rekosh; Pascal O Bessong
Journal:  J Clin Virol       Date:  2018-02-15       Impact factor: 3.168

4.  Evaluation of envelope vaccines derived from the South African subtype C human immunodeficiency virus type 1 TV1 strain.

Authors:  Ying Lian; Indresh Srivastava; V Rául Gómez-Román; Jan Zur Megede; Yide Sun; Elaine Kan; Susan Hilt; Susan Engelbrecht; Sunee Himathongkham; Paul A Luciw; Gillis Otten; Jeffrey B Ulmer; John J Donnelly; Dietmar Rabussay; David Montefiori; Estrelita Janse van Rensburg; Susan W Barnett
Journal:  J Virol       Date:  2005-11       Impact factor: 5.103

5.  Glycosylation site-specific analysis of clade C HIV-1 envelope proteins.

Authors:  Eden P Go; Qing Chang; Hua-Xin Liao; Laura L Sutherland; S Munir Alam; Barton F Haynes; Heather Desaire
Journal:  J Proteome Res       Date:  2009-09       Impact factor: 4.466

6.  Hierarchical targeting of subtype C human immunodeficiency virus type 1 proteins by CD8+ T cells: correlation with viral load.

Authors:  Agatha Masemola; Tumelo Mashishi; Greg Khoury; Phineas Mohube; Pauline Mokgotho; Efthyia Vardas; Mark Colvin; Lynn Zijenah; David Katzenstein; Rosemary Musonda; Susan Allen; Newton Kumwenda; Taha Taha; Glenda Gray; James McIntyre; Salim Abdool Karim; Haynes W Sheppard; Clive M Gray
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

7.  Unequal evolutionary rates in the human immunodeficiency virus type 1 (HIV-1) pandemic: the evolutionary rate of HIV-1 slows down when the epidemic rate increases.

Authors:  Irina Maljkovic Berry; Ruy Ribeiro; Moulik Kothari; Gayathri Athreya; Marcus Daniels; Ha Youn Lee; William Bruno; Thomas Leitner
Journal:  J Virol       Date:  2007-07-18       Impact factor: 5.103

8.  Generation and Characterization of a Bivalent HIV-1 Subtype C gp120 Protein Boost for Proof-of-Concept HIV Vaccine Efficacy Trials in Southern Africa.

Authors:  Carlo Zambonelli; Antu K Dey; Susan Hilt; Samuel Stephenson; Eden P Go; Daniel F Clark; Mark Wininger; Celia Labranche; David Montefiori; Hua-Xin Liao; Ronald I Swanstrom; Heather Desaire; Barton F Haynes; Andrea Carfi; Susan W Barnett
Journal:  PLoS One       Date:  2016-07-21       Impact factor: 3.240

9.  The PTAP sequence duplication in HIV-1 subtype C Gag p6 in drug-naive subjects of India and South Africa.

Authors:  Shilpee Sharma; Shambhu G Aralaguppe; Melissa-Rose Abrahams; Carolyn Williamson; Clive Gray; Pachamuthu Balakrishnan; Shanmugam Saravanan; Kailapuri G Murugavel; Suniti Solomon; Udaykumar Ranga
Journal:  BMC Infect Dis       Date:  2017-01-24       Impact factor: 3.090

10.  Characterization update of HIV-1 M subtypes diversity and proposal for subtypes A and D sub-subtypes reclassification.

Authors:  Nathalie Désiré; Lorenzo Cerutti; Quentin Le Hingrat; Marine Perrier; Stefan Emler; Vincent Calvez; Diane Descamps; Anne-Geneviève Marcelin; Stéphane Hué; Benoit Visseaux
Journal:  Retrovirology       Date:  2018-12-22       Impact factor: 4.602
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.