| Literature DB >> 11708933 |
M Koufaki1, T Calogeropoulou, A Detsi, A Roditis, A P Kourounakis, P Papazafiri, K Tsiakitzis, C Gaitanaki, I Beis, P N Kourounakis.
Abstract
A series of new compounds that contain lipoic acid and trolox connected through spacers were synthesized and examined for their antioxidant activity and their protective effects against reperfusion arrhythmias in isolated heart preparations. All compounds tested are strong inhibitors of lipid peroxidation in rat liver microsomal membranes induced by ferrous ions and ascorbate. N-(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carbonyl)-N'-(1,2-dithiolane-3-pentanoyl)-1,2-phenylenediamine (13) exhibits anti-lipid peroxidation activity at the nanomolar range. N-(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carbonyl)-N'-(1,2-dithiolane-3-pentanoyl)ethylenediamine (10) and 13 totally suppressed reperfusion arrhythmias.Entities:
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Year: 2001 PMID： 11708933 DOI： 10.1021/jm010962w
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446