| Literature DB >> 11708929 |
B Golankiewicz1, T Ostrowski, T Goslinski, P Januszczyk, J Zeidler, D Baranowski, E de Clercq.
Abstract
Of a series of new guanine base modified tricyclic analogues of acyclovir (ACV, 1) and ganciclovir (GCV, 2), derivatives of the 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purine system, evaluated for activity against herpes simplex virus type 1 and 2, several fluorescent analogues, 6-(4-MeOPh)-TACV (8), 7-Me-6-Ph-TACV (17), 6-(4-MeOPh)-TGCV (27), and 7-Me-6-Ph-TGCV (28), were obtained that showed similar potency and selectivity as the parent compounds. The activity was found to be strongly dependent on the nature and steric demands of the substituents in the 6 and/or 7 position.Entities:
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Year: 2001 PMID： 11708929 DOI： 10.1021/jm010922s
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446