| Literature DB >> 11708831 |
S R Abner1, G Parthasarathy, D E Hill, L S Mansfield.
Abstract
Antibacterial activity was detected in excretory-secretory products (ESP) of adult Trichuris suis cultured in vitro in serum-free media. Gram-negative bacteria (Campylobacter jejuni, Campylobacter coli, and Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) were sensitive to ESP. Susceptibility was dependent on the concentration of ESP but not on the inoculum size. Preliminary assessment of the mode of action suggests a bacteriocidal mechanism. This antibacterial activity was heat stable and resistant to digestion with pronase E and trypsin. Based on ultrafiltration experiments, the activity is less than 10,000 MW. This excreted/secreted antibacterial activity from T. suis is likely a component of a humoral defense system for this helminth. Copyright 2001 Academic Press.Entities:
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Year: 2001 PMID： 11708831 DOI： 10.1006/expr.2001.4643
Source DB: PubMed Journal: Exp Parasitol ISSN： 0014-4894 Impact factor: 2.011