Literature DB >> 11708618

The Gompertz function does not measure ageing.

C Driver1.   

Abstract

The Gompertz transform of the distribution function for the age at death expresses mortality in a form R = R0e(alphat) where R0 is the mortality at time zero and alpha is the rate of increase of mortality, frequently taken as the rate of ageing. The slope of the line alpha is frequently used as a measure of the rate of ageing. It is argued that it is incorrect to use alpha in this way. To support this contention, a paradox is produced whereby selection for longevity increases alpha, which could lead to the absurd conclusion that selection for longevity increases the rate of ageing.

Mesh:

Year:  2001        PMID: 11708618     DOI: 10.1023/a:1010061019002

Source DB:  PubMed          Journal:  Biogerontology        ISSN: 1389-5729            Impact factor:   4.277


  4 in total

1.  Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates.

Authors:  Bryan G Hughes; Siegfried Hekimi
Journal:  Genetics       Date:  2016-09-16       Impact factor: 4.562

2.  Genetic association analysis of human longevity in cohort studies of elderly subjects: an example of the PON1 gene in the Danish 1905 birth cohort.

Authors:  Qihua Tan; Lene Christiansen; Lise Bathum; Shuxia Li; Torben A Kruse; Kaare Christensen
Journal:  Genetics       Date:  2005-12-30       Impact factor: 4.562

3.  Oxidative damage, aging and anti-aging strategies.

Authors:  Ronny Haenold; D Mokhtar Wassef; Stefan H Heinemann; Toshinori Hoshi
Journal:  Age (Dordr)       Date:  2005-12-31

4.  Measuring aging rates of mice subjected to caloric restriction and genetic disruption of growth hormone signaling.

Authors:  Jacob J E Koopman; Diana van Heemst; David van Bodegom; Michael S Bonkowski; Liou Y Sun; Andrzej Bartke
Journal:  Aging (Albany NY)       Date:  2016-03       Impact factor: 5.682

  4 in total

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