Literature DB >> 11706074

Integrin alpha(v)beta(3) expression in colon carcinoma correlates with survival.

A Vonlaufen1, G Wiedle, B Borisch, S Birrer, P Luder, B A Imhof.   

Abstract

Integrin alpha(v)beta(3) is expressed by newly formed blood vessels in diseased and neoplastic tissue and can therefore be used as a marker for angiogenesis. We investigated its expression on the vasculature of 40 colon carcinomas using the anti-alpha(v)beta(3)-specific monoclonal antibody LM609. The average relapse-free interval and overall survival in patients suffering from colon carcinomas with high vascular expression of alpha(v)beta(3) integrin was significantly reduced compared with that in patients with low alpha(v)beta(3) integrin expressing tumor vasculature. Moreover, the expression level of alpha(v)beta(3) integrin correlated with the presence of liver metastases. In conclusion, we propose vascular expression of alpha(v)beta(3) integrin as a prognostic indicator for colon carcinoma.

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Year:  2001        PMID： 11706074     DOI： 10.1038/modpathol.3880447

Source DB:  PubMed          Journal:  Mod Pathol        ISSN： 0893-3952            Impact factor:   7.842


  35 in total

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Journal:  Tumour Biol       Date:  2012-06-07

2.  PI3K/Akt/mTOR Signaling and Plasma Membrane Proteins Are Implicated in Responsiveness to Adjuvant Dendritic Cell Vaccination for Metastatic Colorectal Cancer.

Authors:  David C Qian; Xiangjun Xiao; Jinyoung Byun; Arief A Suriawinata; Stephanie C Her; Christopher I Amos; Richard J Barth
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3.  Genetic variants associated with colorectal brain metastases susceptibility and survival.

Authors:  S Stremitzer; A S Berghoff; N B Volz; W Zhang; D Yang; S Stintzing; Y Ning; Y Sunakawa; S Yamauchi; A Sebio; S Matsusaka; S Okazaki; D Hanna; A Parekh; A Mendez; M D Berger; R El-Khoueiry; P Birner; M Preusser; H-J Lenz
Journal:  Pharmacogenomics J       Date:  2015-12-22       Impact factor: 3.550

4.  Angiogenesis and the growth potential of craniopharyngiomas.

Authors:  Sergio Vidal; Bernd W Scheithauer; Kalman Kovacs; Ricardo V Lloyd
Journal:  Endocr Pathol       Date:  2005       Impact factor: 3.943

5.  Near-Infrared Confocal Laser Endomicroscopy Detects Colorectal Cancer via an Integrin αvβ 3 Optical Probe.

Authors:  Petra Schulz; Cordula Dierkes; Bertram Wiedenmann; Carsten Grötzinger
Journal:  Mol Imaging Biol       Date:  2015-08       Impact factor: 3.488

6.  Prognostic value of tumor-related molecular expression in gastric carcinoma.

Authors:  Zhong-Sheng Zhao; Yuan-Yu Wang; Zai-Yuan Ye; Hou-Quan Tao
Journal:  Pathol Oncol Res       Date:  2009-03-18       Impact factor: 3.201

7.  Dual in vivo quantification of integrin-targeted and protease-activated agents in cancer using fluorescence molecular tomography (FMT).

Authors:  Sylvie Kossodo; Maureen Pickarski; Shu-An Lin; Alexa Gleason; Renee Gaspar; Chiara Buono; Guojie Ho; Agnieszka Blusztajn; Garry Cuneo; Jun Zhang; Jayme Jensen; Richard Hargreaves; Paul Coleman; George Hartman; Milind Rajopadhye; Le Thi Duong; Cyrille Sur; Wael Yared; Jeffrey Peterson; Bohumil Bednar
Journal:  Mol Imaging Biol       Date:  2009-12-04       Impact factor: 3.488

8.  The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.

Authors:  Jun Saegusa; Satoshi Yamaji; Katsuaki Ieguchi; Chun-Yi Wu; Kit S Lam; Fu-Tong Liu; Yoko K Takada; Yoshikazu Takada
Journal:  J Biol Chem       Date:  2009-07-03       Impact factor: 5.157

9.  Prognostic value of β1 integrin expression in colorectal liver metastases.

Authors:  Nikolaos Vassos; Tilman Rau; Susanne Merkel; Fabian Feiersinger; Carol I Geppert; Michael Stürzl; Werner Hohenberger; Roland S Croner
Journal:  Int J Clin Exp Pathol       Date:  2013-12-15

10.  Imaging of integrin alpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography.

Authors:  Oliver Schnell; Bjarne Krebs; Janette Carlsen; Isabelle Miederer; Claudia Goetz; Roland H Goldbrunner; Hans-Jürgen Wester; Roland Haubner; Gabriele Pöpperl; Markus Holtmannspötter; Hans A Kretzschmar; Horst Kessler; Jörg-Christian Tonn; Markus Schwaiger; Ambros J Beer
Journal:  Neuro Oncol       Date:  2009-12       Impact factor: 12.300
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