Literature DB >> 11705983

Multiple overlapping epitopes in the repetitive unit of the shed acute-phase antigen from Trypanosoma cruzi enhance its immunogenic properties.

P Alvarez1, M S Leguizamón, C A Buscaglia, T A Pitcovsky, O Campetella.   

Abstract

The repetitive shed acute-phase antigen (SAPA) from Trypanosoma cruzi was thoroughly mapped by SPOT peptides and phage display strategies, showing that a single SAPA repeat is composed of multiple overlapping B-cell epitopes. We propose that this intricate antigenic structure constitutes an alternative device to repetitiveness in order to improve its immunogenicity.

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Year:  2001        PMID： 11705983      PMCID： PMC98897          DOI： 10.1128/IAI.69.12.7946-7949.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

1.  Mimicking of discontinuous epitopes by phage-displayed peptides, I. Epitope mapping of human H ferritin using a phage library of constrained peptides.

Authors:  A Luzzago; F Felici; A Tramontano; A Pessi; R Cortese
Journal:  Gene       Date:  1993-06-15       Impact factor: 3.688

2.  The repetitive domain of Trypanosoma cruzi trans-sialidase enhances the immune response against the catalytic domain.

Authors:  C A Buscaglia; O Campetella; M S Leguizamón; A C Frasch
Journal:  J Infect Dis       Date:  1998-02       Impact factor: 5.226

3.  Variation in repeat number within the alpha C protein of group B streptococci alters antigenicity and protective epitopes.

Authors:  C Gravekamp; D S Horensky; J L Michel; L C Madoff
Journal:  Infect Immun       Date:  1996-09       Impact factor: 3.441

4.  Cloning of a major surface-antigen gene of Trypanosoma cruzi and identification of a nonapeptide repeat.

Authors:  D S Peterson; R A Wrightsman; J E Manning
Journal:  Nature       Date:  1986 Aug 7-13       Impact factor: 49.962

Review 5.  The structure and function of proline-rich regions in proteins.

Authors:  M P Williamson
Journal:  Biochem J       Date:  1994-01-15       Impact factor: 3.857

6.  Trans-sialidase from Trypanosoma cruzi induces apoptosis in cells from the immune system in vivo.

Authors:  M S Leguizamón; E Mocetti; H García Rivello; P Argibay; O Campetella
Journal:  J Infect Dis       Date:  1999-10       Impact factor: 5.226

7.  Antigens of Mycobacterium tuberculosis expressed during preclinical tuberculosis: serological immunodominance of proteins with repetitive amino acid sequences.

Authors:  K K Singh; X Zhang; A S Patibandla; P Chien; S Laal
Journal:  Infect Immun       Date:  2001-06       Impact factor: 3.441

8.  Bloodstream Trypanosoma cruzi parasites from mice simultaneously express antigens that are markers of acute and chronic human Chagas disease.

Authors:  M S Leguizamon; O E Campetella; M B Reyes; C F Ibañez; M A Basombrio; J Rincon; A Orn; A C Frasch
Journal:  Parasitology       Date:  1991-06       Impact factor: 3.234

9.  Mapping of a B-cell epitope present in the neuraminidase of Trypanosoma cruzi.

Authors:  R P Prioli; E Ortega-Barria; J S Mejia; M E Pereira
Journal:  Mol Biochem Parasitol       Date:  1992-05       Impact factor: 1.759

10.  Trypanosoma cruzi trans-sialidase: enhancement of virulence in a murine model of Chagas' disease.

Authors:  M Chuenkova; M E Pereira
Journal:  J Exp Med       Date:  1995-05-01       Impact factor: 14.307
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  18 in total

1.  Use of phage display to identify potential Pseudomonas aeruginosa gene products relevant to early cystic fibrosis airway infections.

Authors:  Christiane Beckmann; Mitchell Brittnacher; Robert Ernst; Nicole Mayer-Hamblett; Samuel I Miller; Jane L Burns
Journal:  Infect Immun       Date:  2005-01       Impact factor: 3.441

2.  Mapping antigenic motifs in the trypomastigote small surface antigen from Trypanosoma cruzi.

Authors:  Virginia Balouz; María de Los Milagros Cámara; Gaspar E Cánepa; Santiago J Carmona; Romina Volcovich; Nicolás Gonzalez; Jaime Altcheh; Fernán Agüero; Carlos A Buscaglia
Journal:  Clin Vaccine Immunol       Date:  2015-01-14

Review 3.  Chagas Disease Diagnostic Applications: Present Knowledge and Future Steps.

Authors:  V Balouz; F Agüero; C A Buscaglia
Journal:  Adv Parasitol       Date:  2016-11-14       Impact factor: 3.870

4.  Mapping of B-cell epitopes in a Trypanosoma cruzi immunodominant antigen expressed in natural infections.

Authors:  Mylène Lesénéchal; Laurence Becquart; Xavier Lacoux; Laurent Ladavière; Renata C P Baida; Glaucia Paranhos-Baccalà; José Franco da Silveira
Journal:  Clin Diagn Lab Immunol       Date:  2005-02

Review 5.  Parasite-host glycan interactions during Trypanosoma cruzi infection: trans-Sialidase rides the show.

Authors:  Oscar Campetella; Carlos A Buscaglia; Juan Mucci; María Susana Leguizamón
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2020-01-20       Impact factor: 5.187

6.  The Trypomastigote Small Surface Antigen from Trypanosoma cruzi Improves Treatment Evaluation and Diagnosis in Pediatric Chagas Disease.

Authors:  Virginia Balouz; Luciano J Melli; Romina Volcovich; Guillermo Moscatelli; Samanta Moroni; Nicolás González; Griselda Ballering; Margarita Bisio; Andrés E Ciocchini; Carlos A Buscaglia; Jaime Altcheh
Journal:  J Clin Microbiol       Date:  2017-10-04       Impact factor: 5.948

7.  Diagnostic peptide discovery: prioritization of pathogen diagnostic markers using multiple features.

Authors:  Santiago J Carmona; Paula A Sartor; María S Leguizamón; Oscar E Campetella; Fernán Agüero
Journal:  PLoS One       Date:  2012-12-14       Impact factor: 3.240

8.  Genomic organization and expression profile of the mucin-associated surface protein (masp) family of the human pathogen Trypanosoma cruzi.

Authors:  Daniella C Bartholomeu; Gustavo C Cerqueira; Ana Carolina A Leão; Wanderson D daRocha; Fabiano S Pais; Camila Macedo; Appolinaire Djikeng; Santuza M R Teixeira; Najib M El-Sayed
Journal:  Nucleic Acids Res       Date:  2009-03-31       Impact factor: 16.971

9.  A refined genome phage display methodology delineates the human antibody response in patients with Chagas disease.

Authors:  André Azevedo Reis Teixeira; Luis Rodriguez Carnero; Andréia Kuramoto; Fenny Hui Fen Tang; Carlos Hernique Gomes; Natalia Bueno Pereira; Léa Campos de Oliveira; Regina Garrini; Jhonatas Sirino Monteiro; João Carlos Setubal; Ester Cerdeira Sabino; Renata Pasqualini; Walter Colli; Wadih Arap; Maria Júlia Manso Alves; Edécio Cunha-Neto; Ricardo José Giordano
Journal:  iScience       Date:  2021-05-15

10.  Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells.

Authors:  Daniela A Bermejo; Shaun W Jackson; Melisa Gorosito-Serran; Eva V Acosta-Rodriguez; Maria C Amezcua-Vesely; Blythe D Sather; Akhilesh K Singh; Socheath Khim; Juan Mucci; Denny Liggitt; Oscar Campetella; Mohamed Oukka; Adriana Gruppi; David J Rawlings
Journal:  Nat Immunol       Date:  2013-04-07       Impact factor: 25.606
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