Literature DB >> 11705980

Identification of the sigB operon in Staphylococcus epidermidis: construction and characterization of a sigB deletion mutant.

S Kies1, M Otto, C Vuong, F Götz.   

Abstract

The role of the alternative sigma factor sigma(B) in Staphylococcus epidermidis was investigated by the construction, complementation, and characterization of a sigB deletion mutant. Electrophoretic analyses confirmed a profound influence of sigma(B) on the expression of exoproteins and cytoplasmic proteins. Detailed investigation revealed reduced lipase and enhanced protease activity in the sigma(B) mutant. Furthermore, no significant influence of sigma(B) on heterologous biofilm formation or on the activity of the global regulator agr was detected.

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Year:  2001        PMID： 11705980      PMCID： PMC98894          DOI： 10.1128/IAI.69.12.7933-7936.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  29 in total

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3.  Construction and characterization of an agr deletion mutant of Staphylococcus epidermidis.

Authors:  C Vuong; F Götz; M Otto
Journal:  Infect Immun       Date:  2000-03       Impact factor: 3.441

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9.  Induction of the staphylococcal proteolytic cascade by antimicrobial fatty acids in community acquired methicillin resistant Staphylococcus aureus.

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10.  Whole-Genome Sequence of Staphylococcus epidermidis Tü3298.

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