| Literature DB >> 1170575 |
D J Balfour, A K Khullar, A Longden.
Abstract
The administration of nicotine (0.4 mg/kh) to unstressed rats caused a rise in plasma corticosterone which persisted for 60 minutes and a fall in hippocampal 5-hydroxytryptamine (5-HT) at 45 minutes followed by a rise at 60 minutes. In rats which were stressed by being placed on an elevated platform, nicotine caused a reduction in hippocampal 5-HT at 45 and 75 minutes but did notaffect the plasma corticosterone concentration. Rats studied 16 hours after the last injection of a course of treatment with metypone had much reduced levels of plasma corticosterone and hippocampal 5-HT. Under the present conditions metyrapone also much diminished the effects of nicotine on plasma corticosterone levels in unstressed rats but had little effect on the response to stress.Entities:
Mesh：
Substances：
Year: 1975 PMID： 1170575 DOI： 10.1016/0091-3057(75)90145-8
Source DB: PubMed Journal: Pharmacol Biochem Behav ISSN： 0091-3057 Impact factor: 3.533