| Literature DB >> 11705569 |
G M Lord, T Cook, V M Arlt, H H Schmeiser, G Williams, C D Pusey.
Abstract
We have previously reported occurrence of a specific type of nephropathy due to ingestion of Chinese herbs (Chinese herbal nephropathy [CHN]) in two patients in the UK. These cases highlighted the role of aristolochic acid in causing this nephropathy, which was first described in a Belgian cohort. We now report development of invasive transitional cell carcinoma of the urinary tract associated with the presence of aristolochic acid-DNA adducts in one of these patients. This work clearly shows the carcinogenic potential of aristolochic acid in this new type of nephropathy.Entities:
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Year: 2001 PMID: 11705569 DOI: 10.1016/s0140-6736(01)06576-x
Source DB: PubMed Journal: Lancet ISSN: 0140-6736 Impact factor: 79.321