Literature DB >> 11704965

NOESY on neurotoxins: NMR and conformational assignments of picrotoxins.

N B Perry1, M Aiyaz, D S Kerr, R J Lake, M T Leach.   

Abstract

Nuclear Overhauser effect spectroscopy (NOESY) gave full assignments of the 1H-NMR spectra of the picrotoxane neurotoxins tutin, hyenanchin, picrotoxinin and picrotin, as well as the solution conformations of these compounds, consistent with molecular modelling. Fully assigned 13C-NMR data are reported.

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Year:  2001        PMID： 11704965     DOI： 10.1002/1099-1565(200101/02)12:1<69::AID-PCA563>3.0.CO;2-M

Source DB:  PubMed          Journal:  Phytochem Anal        ISSN： 0958-0344            Impact factor:   3.373


  4 in total

1.  Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor.

Authors:  A J Thompson; R K Duke; S C R Lummis
Journal:  Mol Pharmacol       Date:  2011-04-19       Impact factor: 4.436

2.  Investigation of the possible biological activities of a poisonous South African plant; Hyaenanche globosa (Euphorbiaceae).

Authors:  Saeideh Momtaz; Namrita Lall; Ahmed Hussein; Seyed Nasser Ostad; Mohammad Abdollahi
Journal:  Pharmacogn Mag       Date:  2010-02-13       Impact factor: 1.085

3.  Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors.

Authors:  Shelley H Huang; Trevor M Lewis; Sarah C R Lummis; Andrew J Thompson; Mary Chebib; Graham A R Johnston; Rujee K Duke
Journal:  Neuropharmacology       Date:  2012-07-22       Impact factor: 5.250

4.  Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site.

Authors:  Andrew J Thompson; Gavin E Jarvis; Rujee K Duke; Graham A R Johnston; Sarah C R Lummis
Journal:  Neuropharmacology       Date:  2010-11-05       Impact factor: 5.250
  4 in total

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