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Literature DB >> 11704836

A CREB site in the BRCA1 proximal promoter acts as a constitutive transcriptional element.

Abstract

Transcriptional regulation of the BRCA1 proximal promoter has been suggested to play a role in the decreased expression of BRCA1 observed in sporadic breast cancer. Computer analysis of the sequence of the proximal promoter reveals the presence of a potential CREB site. We have identified CREB/ATF-1 as the factor interacting with this site in nuclear extracts from MCF-7 and T-47D cells. This site is shown to be important for the constitutive expression of the promoter in these cells, as well as in Hep G2 cells. Despite the presence of this site, the BRCA1 promoter is not responsive to cAMP induction. It appears that CREB acts as a constitutive positive element for BRCA1 expression and that any mechanism inactivating CREB function would have a dramatic effect on BRCA1 expression.

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Year: 2001 PMID： 11704836 DOI： 10.1038/sj.onc.1204890

Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867

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Cited

21 in total

1. Induction of heparanase-1 expression by mutant B-Raf kinase: role of GA binding protein in heparanase-1 promoter activation.

Authors: Geetha Rao; Dingxie Liu; Mingzhao Xing; Jordi Tauler; Richard A Prinz; Xiulong Xu
Journal: Neoplasia Date: 2010-11 Impact factor: 5.715

2. Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1.

Authors: Y Deng; J Liu; G Han; S-L Lu; S-Y Wang; S Malkoski; A C Tan; C Deng; X-J Wang; Q Zhang
Journal: Oncogene Date: 2010-09-06 Impact factor: 9.867

3. Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress.

Authors: Kiros Hailemariam; Kenta Iwasaki; Bo-Wen Huang; Kensuke Sakamoto; Yoshiaki Tsuji
Journal: J Cell Sci Date: 2010-10-27 Impact factor: 5.285

4. Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast cancer.

Authors: Yu Deng; Hui Deng; Jing Liu; Gangwen Han; Stephen Malkoski; Bolin Liu; Rui Zhao; Xiao-Jing Wang; Qinghong Zhang
Journal: Mol Carcinog Date: 2011-06-16 Impact factor: 4.784

5. Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2.

Authors: Jan-Jan Liu; Cheng-Kai Wang; Yu-Tsen Lin; Shang-Chih Yang; Su-Yi Tsai; Wei-Ju Chen; Wei-Kai Huang; Po-Wen A Tu; Yu-Chen Lin; Ching-Fang Chang; Chih-Lun Cheng; Hsuan Lin; Chien-Ying Lai; Chun-Yu Lin; Yi-Hsuan Lee; Yen-Chun Chiu; Chiao-Ching Hsu; Shu-Ching Hsu; Michael Hsiao; Scott C Schuyler; Frank Leigh Lu; Jean Lu
Journal: FASEB J Date: 2019-06-26 Impact factor: 5.191

10. Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites.

Authors: Matteo Rossi; Oleg N Demidov; Carl W Anderson; Ettore Appella; Sharlyn J Mazur
Journal: Nucleic Acids Res Date: 2008-11-10 Impact factor: 16.971

A CREB site in the BRCA1 proximal promoter acts as a constitutive transcriptional element.

1. Induction of heparanase-1 expression by mutant B-Raf kinase: role of GA binding protein in heparanase-1 promoter activation.

2. Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1.

3. Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress.

4. Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast cancer.

5. Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2.

6. A Role of CREB in BRCA1 Constitutive Promoter Activity and Aromatase Basal Expression.

7. PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element.

8. Methylation-sensitive regulation of TMS1/ASC by the Ets factor, GA-binding protein-alpha.

9. CREB binding and activity in brain: regional specificity and induction by electroconvulsive seizure.

10. Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites.