| Literature DB >> 11704344 |
J Tchekalarova1, T Kambourova, V Georgiev.
Abstract
The effects of angiotensin (ANG) III and ANG IV on pentylenetetrazol (PTZ) seizure susceptibility--threshold and kindling in mice--as well as the influence of adenosine A(1) receptor agents (agonist and antagonist) on these effects were studied. It was found that ANG III and ANG IV increased dose-dependently the PTZ seizure threshold and decreased the seizure intensity in PTZ kindled mice. Cyclohexyladenosine (CHA), an adenosine A(1) receptor agonist, potentiated the effects of ANG III and ANG IV on the seizure threshold and kindling, whereas DPCPX (an A(1) receptor antagonist) reversed peptide-induced effects on the PTZ kindling. Taken together, ANG III and ANG IV decrease the PTZ seizure susceptibility. We could suggest that these effects are realized in part through interaction with adenosine A(1) receptors.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11704344 DOI： 10.1016/s0361-9230(01)00568-8
Source DB: PubMed Journal: Brain Res Bull ISSN： 0361-9230 Impact factor: 4.077