D Qin1, G Ou, H Mo, Y Song, G Kang, Y Hu, X Gu. 1. Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China. qindexing@263.net
Abstract
PURPOSE: To improve the efficacy of chemotherapy for glioblastoma through the radiation-induced opening of the blood-brain barrier (BBB). METHODS AND MATERIALS: In two previous articles, we have described the results of brain scanning using technetium 99m-labeled somatostatin and the measurement of methotrexate (MTX) concentrations in blood and cerebrospinal fluid (CSF) after i.v. injection. We discovered that the BBB and blood-cerebrospinal fluid barrier opened to a certain extent after 20- to 40-Gy irradiation, thus increasing the degree to which MTX permeated the brain tissue. On the basis of these findings, we retrospectively analyzed the outcome in 56 patients with glioblastoma given either chemotherapy (CCNU) after 20- to 40-Gy irradiation (28 patients) or radiation therapy alone (28 patients). RESULTS: The 1-, 3-, and 5-year survival rates were 57.14%, 22.50%, and 15.00% in the combined-therapy group and 17.86%, 7.14%, and 3.57% in the radiotherapy alone group, respectively. The respective median survival times were 29.11 +/- 6.99 and 9.86 +/- 3.45 months (p < 0.001), which represented a statistically significant difference. CONCLUSION: Our study further confirms that opening of the BBB induced by irradiation with 20-40 Gy may optimize the effects of intracranial chemotherapy.
PURPOSE: To improve the efficacy of chemotherapy for glioblastoma through the radiation-induced opening of the blood-brain barrier (BBB). METHODS AND MATERIALS: In two previous articles, we have described the results of brain scanning using technetium 99m-labeled somatostatin and the measurement of methotrexate (MTX) concentrations in blood and cerebrospinal fluid (CSF) after i.v. injection. We discovered that the BBB and blood-cerebrospinal fluid barrier opened to a certain extent after 20- to 40-Gy irradiation, thus increasing the degree to which MTX permeated the brain tissue. On the basis of these findings, we retrospectively analyzed the outcome in 56 patients with glioblastoma given either chemotherapy (CCNU) after 20- to 40-Gy irradiation (28 patients) or radiation therapy alone (28 patients). RESULTS: The 1-, 3-, and 5-year survival rates were 57.14%, 22.50%, and 15.00% in the combined-therapy group and 17.86%, 7.14%, and 3.57% in the radiotherapy alone group, respectively. The respective median survival times were 29.11 +/- 6.99 and 9.86 +/- 3.45 months (p < 0.001), which represented a statistically significant difference. CONCLUSION: Our study further confirms that opening of the BBB induced by irradiation with 20-40 Gy may optimize the effects of intracranial chemotherapy.
Authors: In Young Kim; You Jung Kang; Mi Jin Yoon; Eun Hee Kim; Seung U Kim; Taeg Kyu Kwon; In Ah Kim; Kyeong Sook Choi Journal: Neuro Oncol Date: 2011-02-03 Impact factor: 12.300
Authors: Raphaël Serduc; Elke Bräuer-Krisch; Erik A Siegbahn; Audrey Bouchet; Benoit Pouyatos; Romain Carron; Nicolas Pannetier; Luc Renaud; Gilles Berruyer; Christian Nemoz; Thierry Brochard; Chantal Rémy; Emmanuel L Barbier; Alberto Bravin; Géraldine Le Duc; Antoine Depaulis; François Estève; Jean A Laissue Journal: PLoS One Date: 2010-02-03 Impact factor: 3.240
Authors: Deepak Kanojia; Wojciech K Panek; Alex Cordero; Jawad Fares; Annie Xiao; Solomiia Savchuk; Krishan Kumar; Ting Xiao; Katarzyna C Pituch; Jason Miska; Peng Zhang; Kwok-Ling Kam; Craig Horbinski; Irina V Balyasnikova; Atique U Ahmed; Maciej S Lesniak Journal: Sci Transl Med Date: 2020-08-26 Impact factor: 17.956
Authors: Tarun Ojha; Vertika Pathak; Yang Shi; Wim E Hennink; Chrit T W Moonen; Gert Storm; Fabian Kiessling; Twan Lammers Journal: Adv Drug Deliv Rev Date: 2017-07-08 Impact factor: 15.470