PURPOSE: To report an unusual ocular presentation of Candida glabrata in a patient with chronic granulomatous disease. METHODS: Interventional case report. A 15-year-old boy with chronic granulomatous disease presented with bilateral limbal infiltrates. He had been receiving broad-spectrum systemic antibiotics for recurrent liver abscesses. The keratitis did not respond to antibiotics and did not resolve after a course of topical steroids. RESULTS: Corneal cultures revealed Candida glabrata. The same species was simultaneously isolated from the surgical drainage of the liver abscesses. The ocular and hepatic findings resolved on intravenous amphotericin B. CONCLUSION: Candida glabrata has recently emerged as an important nosocomial pathogen. It may present as a limbal keratitis in the setting of systemic infection.
PURPOSE: To report an unusual ocular presentation of Candida glabrata in a patient with chronic granulomatous disease. METHODS: Interventional case report. A 15-year-old boy with chronic granulomatous disease presented with bilateral limbal infiltrates. He had been receiving broad-spectrum systemic antibiotics for recurrent liver abscesses. The keratitis did not respond to antibiotics and did not resolve after a course of topical steroids. RESULTS: Corneal cultures revealed Candida glabrata. The same species was simultaneously isolated from the surgical drainage of the liver abscesses. The ocular and hepatic findings resolved on intravenous amphotericin B. CONCLUSION:Candida glabrata has recently emerged as an important nosocomial pathogen. It may present as a limbal keratitis in the setting of systemic infection.
Authors: Ying-Lien Chen; Jay H Konieczka; Deborah J Springer; Samantha E Bowen; Jing Zhang; Fitz Gerald S Silao; Alice Alma C Bungay; Ursela G Bigol; Marilou G Nicolas; Soman N Abraham; Dawn A Thompson; Aviv Regev; Joseph Heitman Journal: G3 (Bethesda) Date: 2012-06-01 Impact factor: 3.154
Authors: Hung-Jui Hsu; Chia-Yi Lee; Kun-Lin Yang; Hung-Chi Chen; Chi-Chin Sun; Jing-Yang Huang; Hung-Yu Lin; Shun-Fa Yang Journal: Int J Environ Res Public Health Date: 2019-04-05 Impact factor: 3.390