Literature DB >> 11703841

Biochemical and molecular mechanisms of drug resistance in parasites.

M Ouellette1.   

Abstract

Drug resistance is complicating the treatment of parasitic diseases. We review here the basic mechanisms of parasite resistance in malaria, sleeping sickness, leishmaniasis and common helminthiases. Parasites resort to multiple biochemical means to achieve resistance and we have begun to isolate and characterize the genes/proteins implicated in resistance. Understanding drug resistance is essential for the control of parasitic diseases.

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Year:  2001        PMID： 11703841     DOI： 10.1046/j.1365-3156.2001.00777.x

Source DB:  PubMed          Journal:  Trop Med Int Health        ISSN： 1360-2276            Impact factor:   2.622


  20 in total

1.  Structural and functional analysis of an amplification containing a PGPA gene in a glucantime-resistant Leishmania (Viannia) guyanensis cell line.

Authors:  Charles Anacleto; Maria C B Abdo; Adlane V B Ferreira; Silvane M F Murta; Alvaro J Romanha; Ana Paula Fernandes; Elizabeth S A Moreira
Journal:  Parasitol Res       Date:  2003-02-11       Impact factor: 2.289

Review 2.  Understanding drug resistance in human intestinal protozoa.

Authors:  Hend Aly El-Taweel
Journal:  Parasitol Res       Date:  2015-03-19       Impact factor: 2.289

3.  Alterations in Plasmodium falciparum genetic structure two years after increased malaria control efforts in western Kenya.

Authors:  Anne M Vardo-Zalik; Guofa Zhou; Daibin Zhong; Yaw A Afrane; Andrew K Githeko; Guiyun Yan
Journal:  Am J Trop Med Hyg       Date:  2012-11-19       Impact factor: 2.345

4.  Antileishmanial effect of 3-aminooxy-1-aminopropane is due to polyamine depletion.

Authors:  Sushma Singh; Angana Mukherjee; Alex R Khomutov; Lo Persson; Olle Heby; Mitali Chatterjee; Rentala Madhubala
Journal:  Antimicrob Agents Chemother       Date:  2006-11-13       Impact factor: 5.191

5.  Differential effects of paromomycin on ribosomes of Leishmania mexicana and mammalian cells.

Authors:  Marisa M Fernández; Emilio L Malchiodi; Israel D Algranati
Journal:  Antimicrob Agents Chemother       Date:  2010-10-18       Impact factor: 5.191

6.  Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes.

Authors:  Laura Ceballos; Laura Moreno; Luis Alvarez; Laura Shaw; Ian Fairweather; Carlos Lanusse
Journal:  BMC Vet Res       Date:  2010-02-03       Impact factor: 2.741

7.  Vinyl sulfones as antiparasitic agents and a structural basis for drug design.

Authors:  Iain D Kerr; Ji H Lee; Christopher J Farady; Rachael Marion; Mathias Rickert; Mohammed Sajid; Kailash C Pandey; Conor R Caffrey; Jennifer Legac; Elizabeth Hansell; James H McKerrow; Charles S Craik; Philip J Rosenthal; Linda S Brinen
Journal:  J Biol Chem       Date:  2009-07-20       Impact factor: 5.157

8.  Genetic structure of Plasmodium falciparum populations between lowland and highland sites and antimalarial drug resistance in Western Kenya.

Authors:  Mariangela Bonizzoni; Yaw Afrane; Frederick N Baliraine; Dolphine A Amenya; Andrew K Githeko; Guiyun Yan
Journal:  Infect Genet Evol       Date:  2009-05-04       Impact factor: 3.342

9.  Gene expression study using real-time PCR identifies an NTR gene as a major marker of resistance to benzonidazole in Trypanosoma cruzi.

Authors:  Ana M Mejía-Jaramillo; Geysson J Fernández; Lina Palacio; Omar Triana-Chávez
Journal:  Parasit Vectors       Date:  2011-09-05       Impact factor: 3.876

10.  Inhibition of Leishmania major PTR1 Gene Expression by Antisense in Escherichia coli.

Authors:  F Kheirandish; M Bandehpour; A Haghighi; F Mahboudi; M Mohebali; B Kazemi
Journal:  Iran J Public Health       Date:  2012-06-30       Impact factor: 1.429
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