Literature DB >> 11703351

High expression of platelet-derived growth factor and transforming growth factor-beta 1 in blast cells from patients with Down Syndrome suffering from transient myeloproliferative disorder and organ fibrosis.

H Hattori1, A Matsuzaki, A Suminoe, K Ihara, H Nakayama, T Hara.   

Abstract

To determine whether platelet-derived growth factor (PDGF) and transforming growth factor-beta 1 (TGF-beta 1) are involved in organ fibrosis in patients with transient myeloproliferative disorder (TMD) in Down syndrome, the expression of PDGF and TGF-beta 1 mRNA in blast cells of TMD was investigated using real-time quantitative reverse transcription polymerase chain reaction. Blasts and liver tissue from TMD patients with hepatic fibrosis showed a significantly elevated expression of PDGF gene. The expression of TGF-beta 1 gene was higher in TMD and acute megakaryoblastic leukaemia than in the control group. These results suggest that PDGF in combination with TGF-beta 1 plays a role in organ fibrosis of TMD.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11703351     DOI： 10.1046/j.1365-2141.2001.03093.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  7 in total

1.  Novel roles of osteopontin and CXC chemokine ligand 7 in the defence against mycobacterial infection.

Authors:  V Khajoee; M Saito; H Takada; A Nomura; K Kusuhara; S-I Yoshida; Y Yoshikai; T Hara
Journal:  Clin Exp Immunol       Date:  2006-02       Impact factor: 4.330

2.  Liver disease is frequently observed in Down syndrome patients with transient abnormal myelopoiesis.

Authors:  Myoung Ja Park; Manabu Sotomatsu; Kentaro Ohki; Kokoro Arai; Kenichi Maruyama; Tomio Kobayashi; Akira Nishi; Kiyoko Sameshima; Takeshi Takagi; Yasuhide Hayashi
Journal:  Int J Hematol       Date:  2013-12-14       Impact factor: 2.490

3.  Microarray analysis of human milk cells: persistent high expression of osteopontin during the lactation period.

Authors:  T Nagatomo; S Ohga; H Takada; A Nomura; S Hikino; M Imura; K Ohshima; T Hara
Journal:  Clin Exp Immunol       Date:  2004-10       Impact factor: 4.330

4.  Novel insights from fetal and placental phenotyping in 3 mouse models of Down syndrome.

Authors:  April D Adams; Victoria Hoffmann; Laura Koehly; Faycal Guedj; Diana W Bianchi
Journal:  Am J Obstet Gynecol       Date:  2021-03-22       Impact factor: 10.693

5.  Role of monocyte chemoattractant protein-1 in liver fibrosis with transient myeloproliferative disorder in down syndrome.

Authors:  Kenichiro Kobayashi; Takako Yoshioka; Jun Miyauchi; Atsuko Nakazawa; Nobutaka Kiyokawa; Toshiro Maihara; Ikuya Usami
Journal:  Hepatol Commun       Date:  2018-02-01

6.  Influence of Silica Exposure for Lung Silicosis Rat.

Authors:  Jie Jiao; Li Li; Wu Yao; Weidong Qin; Changfu Hao; Lingeng Lu
Journal:  Dis Markers       Date:  2021-12-13       Impact factor: 3.434

7.  Maternal plasma angiogenic and inflammatory factor profiling in foetal Down syndrome.

Authors:  Monika Zbucka-Kretowska; Karol Charkiewicz; Joanna Goscik; Slawomir Wolczynski; Piotr Laudanski
Journal:  PLoS One       Date:  2017-12-15       Impact factor: 3.240
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.