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Literature DB >> 11701932

Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes.

S J Davies¹, J L Grogan, R B Blank, K C Lim, R M Locksley, J H McKerrow.

Abstract

We have identified an alternate developmental pathway in the life cycle of the trematode pathogen Schistosoma mansoni. This pathway is used in immunodeficient hosts in which the parasite fails to receive appropriate signals from the host immune system. Helminth development is altered at an early stage during infection, resulting in the appearance of attenuated forms that prolong survival of host and parasite. Hepatic CD4+ T lymphocyte populations are an integral component of the immune signal recognized by the parasite.

Entities: Disease Species

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Year: 2001 PMID： 11701932 DOI： 10.1126/science.1064462

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

61 in total

Review 1. Developmental plasticity in schistosomes and other helminths.

Authors: Stephen J Davies; James H McKerrow
Journal: Int J Parasitol Date: 2003-09-30 Impact factor: 3.981

2. Schistosoma mansoni: sex-specific modulation of parasite growth by host immune signals.

Authors: David C Hernandez; K C Lim; James H McKerrow; Stephen J Davies
Journal: Exp Parasitol Date: 2004 Jan-Feb Impact factor: 2.011

3. Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite-induced cholangiocarcinoma in humans.

Authors: Sujit S Nair; Anitha Bommana; Suresh B Pakala; Kazufumi Ohshiro; Amanda J Lyon; Sutas Suttiprapa; Maria V Periago; Thewarach Laha; Peter J Hotez; Jeffrey M Bethony; Banchob Sripa; Paul J Brindley; Rakesh Kumar
Journal: Hepatology Date: 2011-09-06 Impact factor: 17.425

9. Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy.

Authors: Simon A Babayan; Andrew F Read; Rachel A Lawrence; Odile Bain; Judith E Allen
Journal: PLoS Biol Date: 2010-10-19 Impact factor: 8.029

10. A schistosome cAMP-dependent protein kinase catalytic subunit is essential for parasite viability.

Authors: Brett E Swierczewski; Stephen J Davies
Journal: PLoS Negl Trop Dis Date: 2009-08-25

Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes.

Review 1. Developmental plasticity in schistosomes and other helminths.

2. Schistosoma mansoni: sex-specific modulation of parasite growth by host immune signals.

3. Inflammatory response to liver fluke Opisthorchis viverrini in mice depends on host master coregulator MTA1, a marker for parasite-induced cholangiocarcinoma in humans.

4. The Schistosoma japonicum genome reveals features of host-parasite interplay.

5. Blood fluke exploitation of non-cognate CD4+ T cell help to facilitate parasite development.

6. Cloning and characterisation of Schistosoma japonicum insulin receptors.

7. Parasite evolution and life history theory.

8. Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection.

9. Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy.

10. A schistosome cAMP-dependent protein kinase catalytic subunit is essential for parasite viability.