Literature DB >> 1170003

High intestinal lactase concentrations in adult Arbs in Saudi Arabia.

G C Cook, M T al-Torki.   

Abstract

The maximum rise in blood glucose after 50 g lactose by mouth was determined in 40 adult Arabs. Out of 30 Bedouin, urban Saudi, and Yemeni and 9 of mixed ancestry (usually partly African), 25 (83%) and 2 (22%) respectively showed an increase of over 1-1 mmol/1 (20 mg/100 ml). In common with most northern Europeans and Hamitic people of northern Africa, Arabs in Saudi Arabia usually have high intestinal lactase concentrations in adult life. This persistence of high levels probably originated in the Arabian peninsula. Its selective advantage may have been associated with the fluid and calorie content of camels' milk, which is important for survival in desert nomads.

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Year:  1975        PMID: 1170003      PMCID: PMC1674005          DOI: 10.1136/bmj.3.5976.135

Source DB:  PubMed          Journal:  Br Med J        ISSN: 0007-1447


  4 in total

Review 1.  Malabsorption in Africa.

Authors:  G C Cook
Journal:  Trans R Soc Trop Med Hyg       Date:  1974       Impact factor: 2.184

2.  Lactose nutrition and natural selection.

Authors:  G Flatz; H W Rotthauwe
Journal:  Lancet       Date:  1973-07-14       Impact factor: 79.321

3.  Lactose intolerance in Arabs.

Authors:  H W Rotthauwe; M O el-Schallah; G Flatz
Journal:  Humangenetik       Date:  1971

4.  Lactose tolerance in an Arab population.

Authors:  T Gilat; E G Malachi; S B Shochet
Journal:  Am J Dig Dis       Date:  1971-03
  4 in total
  21 in total

1.  Lactose digestion and the evolutionary genetics of lactase persistence.

Authors:  Catherine J E Ingram; Charlotte A Mulcare; Yuval Itan; Mark G Thomas; Dallas M Swallow
Journal:  Hum Genet       Date:  2008-11-26       Impact factor: 4.132

2.  Persistence of high intestinal lactase activity (lactose tolerance) in Afghanistan.

Authors:  A G Rahimi; H Delbrück; R Haeckel; H W Goedde; G Flatz
Journal:  Hum Genet       Date:  1976-09-10       Impact factor: 4.132

3.  Distribution of adult lactase phenotypes in the Tuareg of Niger.

Authors:  G Flatz; C Schildge; H Sekou
Journal:  Am J Hum Genet       Date:  1986-04       Impact factor: 11.025

Review 4.  The geographic hypothesis and lactose malabsorption. A weighing of the evidence.

Authors:  F J Simoons
Journal:  Am J Dig Dis       Date:  1978-11

5.  Geography and lactose malabsorption.

Authors:  G Flatz; H W Rotthauwe
Journal:  Dig Dis Sci       Date:  1979-06       Impact factor: 3.199

6.  Did malaria select for primary adult lactase deficiency?

Authors:  B Anderson; C Vullo
Journal:  Gut       Date:  1994-10       Impact factor: 23.059

7.  The frequency distribution of lactose malabsorption among adult populations from the eastern and western Egyptian deserts.

Authors:  L Hussein; A Ezzilarab
Journal:  Biochem Genet       Date:  1994-10       Impact factor: 1.890

8.  Prevalence of primary adult lactose malabsorption in three populations of northern China.

Authors:  Y G Wang; Y S Yan; J J Xu; R F Du; S D Flatz; W Kühnau; G Flatz
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

9.  The T/G 13915 variant upstream of the lactase gene (LCT) is the founder allele of lactase persistence in an urban Saudi population.

Authors:  F Imtiaz; E Savilahti; A Sarnesto; D Trabzuni; K Al-Kahtani; I Kagevi; M S Rashed; B F Meyer; I Järvelä
Journal:  J Med Genet       Date:  2007-10       Impact factor: 6.318

10.  Impact of selection and demography on the diffusion of lactase persistence.

Authors:  Pascale Gerbault; Céline Moret; Mathias Currat; Alicia Sanchez-Mazas
Journal:  PLoS One       Date:  2009-07-24       Impact factor: 3.240

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