Literature DB >> 11699889

High-capacity 'gutless' adenoviral vectors.

S Kochanek1, G Schiedner, C Volpers.   

Abstract

Adenoviral vectors are promising gene transfer vehicles for different gene therapy applications. High-capacity adenoviral (HC-Ad) vectors address some of the problems that have been observed with replication-defective, E1-deleted first-generation adenoviral vectors: toxicity and immunogenicity due to viral gene expression and 7 to 8 kb capacity limit for the transport of therapeutic DNA. This review summarizes HC-Ad vector-related publications from the past 18 months that are mainly concerned with vector design/production and in vivo applications in different murine models.

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Year:  2001        PMID： 11699889

Source DB:  PubMed          Journal:  Curr Opin Mol Ther        ISSN： 1464-8431


  30 in total

Review 1.  Immunological hurdles to lung gene therapy.

Authors:  S Ferrari; U Griesenbach; D M Geddes; E Alton
Journal:  Clin Exp Immunol       Date:  2003-04       Impact factor: 4.330

2.  Genome size and structure determine efficiency of postinternalization steps and gene transfer of capsid-modified adenovirus vectors in a cell-type-specific manner.

Authors:  Dmitry M Shayakhmetov; Zong-Yi Li; Anuj Gaggar; Helen Gharwan; Vladimir Ternovoi; Volker Sandig; André Lieber
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

Review 3.  Gene therapy in clinical medicine.

Authors:  S M Selkirk
Journal:  Postgrad Med J       Date:  2004-10       Impact factor: 2.401

Review 4.  A realistic chance for gene therapy in the near future.

Authors:  Stefan Worgall
Journal:  Pediatr Nephrol       Date:  2004-11-10       Impact factor: 3.714

Review 5.  Innate immunity to adenovirus: lessons from mice.

Authors:  Svetlana Atasheva; Jia Yao; Dmitry M Shayakhmetov
Journal:  FEBS Lett       Date:  2019-12-08       Impact factor: 4.124

6.  In vivo transgene expression from an adenoviral vector is altered following a 6-OHDA lesion of the dopamine system.

Authors:  E M Torres; C Monville; P R Lowenstein; M G Castro; S B Dunnett
Journal:  Brain Res Mol Brain Res       Date:  2005-04-18

7.  Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction.

Authors:  M Puntel; J F Curtin; J M Zirger; A K M Muhammad; W Xiong; C Liu; J Hu; K M Kroeger; P Czer; S Sciascia; S Mondkar; P R Lowenstein; M G Castro
Journal:  Hum Gene Ther       Date:  2006-05       Impact factor: 5.695

8.  Tightly regulated gene expression in human hematopoietic stem cells after transduction with helper-dependent Ad5/35 vectors.

Authors:  Hongje Wang; Hua Cao; Martin Wohlfahrt; Hans-Peter Kiem; André Lieber
Journal:  Exp Hematol       Date:  2008-04-18       Impact factor: 3.084

9.  A capsid-modified helper-dependent adenovirus vector containing the beta-globin locus control region displays a nonrandom integration pattern and allows stable, erythroid-specific gene expression.

Authors:  Hongjie Wang; Dmitry M Shayakhmetov; Tobias Leege; Michael Harkey; Qiliang Li; Thalia Papayannopoulou; George Stamatoyannopolous; André Lieber
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

10.  Prospects for the use of artificial chromosomes and minichromosome-like episomes in gene therapy.

Authors:  Sara Pérez-Luz; Javier Díaz-Nido
Journal:  J Biomed Biotechnol       Date:  2010-08-24
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