C Hamann1, U Schönfeld, A H Clarke. 1. Freie Universität Berlin, Universitätsklinikum Benjamin Franklin, Hals-Nasen-Ohrenklinik, Labor für experimentelle Gleichgewichtsforschung, Hindenburgdamm 30, 12200 Berlin. clarke@zedat.fu-berlin.de
Abstract
BACKGROUND: During constant velocity rotation about the earth's vertical axis, eccentric displacement of the head can be used to generate adequate stimulation of the otolith organs. More recently, studies have been performed with a variable radius rotatory chair, which permits a controlled modulation of the centripetal or radial acceleration, to achieve linear acceleration frequencies much lower than with a conventional linear sled. METHODS: In the present study, frequency response and threshold testing was performed using sinusoidal modulation of the chair radius. Three-dimensional eye movements were recorded with binocular video-oculography. RESULTS: The gain (0.09 degree/degree at 0.03 Hz, 0.009 degree/degree at 1 Hz) and phase relationships of the otolith-ocular response (OOR) show a low-pass characteristic over the measured range of 0.03-1.0 Hz. In comparison to the flat response of neurophysiological recordings from the otolith afferent, our findings support the idea that any low-pass filtering of otolith afferents occurs at the level of the vestibular nuclei. CONCLUSION: The OOR could be detected at acceleration levels of 0.03 m/s2, much lower than the subjective threshold for the perception of 0.08 m/s2.
BACKGROUND: During constant velocity rotation about the earth's vertical axis, eccentric displacement of the head can be used to generate adequate stimulation of the otolith organs. More recently, studies have been performed with a variable radius rotatory chair, which permits a controlled modulation of the centripetal or radial acceleration, to achieve linear acceleration frequencies much lower than with a conventional linear sled. METHODS: In the present study, frequency response and threshold testing was performed using sinusoidal modulation of the chair radius. Three-dimensional eye movements were recorded with binocular video-oculography. RESULTS: The gain (0.09 degree/degree at 0.03 Hz, 0.009 degree/degree at 1 Hz) and phase relationships of the otolith-ocular response (OOR) show a low-pass characteristic over the measured range of 0.03-1.0 Hz. In comparison to the flat response of neurophysiological recordings from the otolith afferent, our findings support the idea that any low-pass filtering of otolith afferents occurs at the level of the vestibular nuclei. CONCLUSION: The OOR could be detected at acceleration levels of 0.03 m/s2, much lower than the subjective threshold for the perception of 0.08 m/s2.