Literature DB >> 11697735

Intramolecular i-motif structure at acidic pH for progressive myoclonus epilepsy (EPM1) repeat d(CCCCGCCCCGCG)n.

S S Pataskar1, D Dash, S K Brahmachari.   

Abstract

The most common mutation associated with Progressive Myoclonus Epilepsy (EPM1) of Unverricht-Lundberg type is the expansion of a dodecamer repeat, d(CCCCGCCCCGCG)n. We show that the C-rich strand of this repeat (2-3 copies) forms intercalated i-motif structure at acidic pH as judged by CD spectroscopy and anomalous gel electrophoretic mobility. The stability of the structure increases with the increase in the length of the repeat. Transient formation of stable, folded back structure like i-motif could play an important role in the mechanism of expansion of this repeat.

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Year:  2001        PMID： 11697735     DOI： 10.1080/07391102.2001.10506741

Source DB:  PubMed          Journal:  J Biomol Struct Dyn        ISSN： 0739-1102


  8 in total

1.  Small circular DNAs for synthesis of the human telomere repeat: varied sizes, structures and telomere-encoding activities.

Authors:  Jörg S Hartig; Eric T Kool
Journal:  Nucleic Acids Res       Date:  2004-11-01       Impact factor: 16.971

2.  The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downregulate Gene Expression.

Authors:  Robert V Brown; Ting Wang; Venkateshwar Reddy Chappeta; Guanhui Wu; Buket Onel; Reena Chawla; Hector Quijada; Sara M Camp; Eddie T Chiang; Quinea R Lassiter; Carmen Lee; Shivani Phanse; Megan A Turnidge; Ping Zhao; Joe G N Garcia; Vijay Gokhale; Danzhou Yang; Laurence H Hurley
Journal:  J Am Chem Soc       Date:  2017-05-19       Impact factor: 15.419

3.  Unusual Isothermal Hysteresis in DNA i-Motif pH Transitions: A Study of the RAD17 Promoter Sequence.

Authors:  R Aaron Rogers; Aaron M Fleming; Cynthia J Burrows
Journal:  Biophys J       Date:  2018-04-24       Impact factor: 4.033

4.  Coexistence of an ILPR i-motif and a partially folded structure with comparable mechanical stability revealed at the single-molecule level.

Authors:  Soma Dhakal; Joseph D Schonhoft; Deepak Koirala; Zhongbo Yu; Soumitra Basu; Hanbin Mao
Journal:  J Am Chem Soc       Date:  2010-07-07       Impact factor: 15.419

5.  The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern.

Authors:  Samantha Kendrick; Yoshitsugu Akiyama; Sidney M Hecht; Laurence H Hurley
Journal:  J Am Chem Soc       Date:  2009-12-09       Impact factor: 15.419

6.  Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression.

Authors:  Christine E Kaiser; Natalie A Van Ert; Prashansa Agrawal; Reena Chawla; Danzhou Yang; Laurence H Hurley
Journal:  J Am Chem Soc       Date:  2017-06-15       Impact factor: 15.419

7.  Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene.

Authors:  Kexiao Guo; Vijay Gokhale; Laurence H Hurley; Daekyu Sun
Journal:  Nucleic Acids Res       Date:  2008-07-09       Impact factor: 16.971

8.  Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb).

Authors:  Yan Xu; Hiroshi Sugiyama
Journal:  Nucleic Acids Res       Date:  2006-02-07       Impact factor: 16.971
  8 in total

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