K Plna1, K Hemminki. 1. Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden.
Abstract
PURPOSE: We analyzed the risk of bladder cancer in offspring according to parental and sibling cancer using the national Swedish Family Cancer Database. MATERIALS AND METHODS: Cancer data were obtained from the Swedish Cancer Registry for 1958 to 1996, including 2,105 cases of bladder cancer in offspring. The standardized incidence ratio was used to measure cancer risk in offspring according to familial cancer status. RESULTS: The incidence ratio of bladder cancer increased in Sweden from 1958 to 1996 and it was 3 to 4-fold higher in males than in females. We identified 65 families in which the parents and offspring had bladder cancer with a familial risk of 1.35 (95% confidence interval [CI] 0.97 to 1.79) in sons and 2.29 (95% CI 1.46 to 3.29) in daughters. Discordant cancer sites associated with bladder cancer in the 2 generations were the kidney and thyroid with a standardized incidence ratio of 1.58 (95% CI 1.18 to 2.05) and 1.89 (95% CI 1.00 to 3.05), respectively. Sibling risk was higher compared with offspring risk with a standardized incidence ratio of 2.96 (95% CI 1.41 to 5.08) and in males there was a statistically significant ratio of sibling-to-offspring risk of 2.66 (95% CI 1.29 to 5.45). Patient age at onset modified the familial risk. The highest familial risk of 7.26 (95% CI 2.61 to 14.24) was observed in the brothers of bladder cancer probands diagnosed before age 45 years. CONCLUSIONS: The relatively high ratio of sibling-to-offspring risk as well as observed gender specific effects in bladder cancer may reflect an X linked susceptibility gene.
PURPOSE: We analyzed the risk of bladder cancer in offspring according to parental and sibling cancer using the national Swedish Family Cancer Database. MATERIALS AND METHODS:Cancer data were obtained from the Swedish Cancer Registry for 1958 to 1996, including 2,105 cases of bladder cancer in offspring. The standardized incidence ratio was used to measure cancer risk in offspring according to familial cancer status. RESULTS: The incidence ratio of bladder cancer increased in Sweden from 1958 to 1996 and it was 3 to 4-fold higher in males than in females. We identified 65 families in which the parents and offspring had bladder cancer with a familial risk of 1.35 (95% confidence interval [CI] 0.97 to 1.79) in sons and 2.29 (95% CI 1.46 to 3.29) in daughters. Discordant cancer sites associated with bladder cancer in the 2 generations were the kidney and thyroid with a standardized incidence ratio of 1.58 (95% CI 1.18 to 2.05) and 1.89 (95% CI 1.00 to 3.05), respectively. Sibling risk was higher compared with offspring risk with a standardized incidence ratio of 2.96 (95% CI 1.41 to 5.08) and in males there was a statistically significant ratio of sibling-to-offspring risk of 2.66 (95% CI 1.29 to 5.45). Patient age at onset modified the familial risk. The highest familial risk of 7.26 (95% CI 2.61 to 14.24) was observed in the brothers of bladder cancer probands diagnosed before age 45 years. CONCLUSIONS: The relatively high ratio of sibling-to-offspring risk as well as observed gender specific effects in bladder cancer may reflect an X linked susceptibility gene.
Authors: Sigurdur Y Kristinsson; Lynn R Goldin; Magnus Björkholm; Ingemar Turesson; Ola Landgren Journal: Haematologica Date: 2009-06-22 Impact factor: 9.941
Authors: Christopher Martin; Claire L Leiser; Brock O'Neil; Sumati Gupta; William T Lowrance; Wendy Kohlmann; Samantha Greenberg; Piyush Pathak; Ken R Smith; Heidi A Hanson Journal: J Natl Cancer Inst Date: 2018-05-01 Impact factor: 13.506
Authors: Sigurdur Y Kristinsson; Magnus Björkholm; Lynn R Goldin; Cecilie Blimark; Ulf-Henrik Mellqvist; Anders Wahlin; Ingemar Turesson; Ola Landgren Journal: Int J Cancer Date: 2009-11-01 Impact factor: 7.396
Authors: Maria I Carlo; Vignesh Ravichandran; Preethi Srinavasan; Chaitanya Bandlamudi; Yelena Kemel; Ozge Ceyhan-Birsoy; Semanti Mukherjee; Diana Mandelker; Joshua Chaim; Andrea Knezevic; Satshil Rana; Zarina Fnu; Kelsey Breen; Angela G Arnold; Aliya Khurram; Kaitlyn Tkachuk; Catharine K Cipolla; Ashley Regazzi; A Ari Hakimi; Hikmat Al-Ahmadie; Guido Dalbagni; Karen A Cadoo; Michael F Walsh; Min-Yuen Teo; Samuel A Funt; Jonathan A Coleman; Bernard H Bochner; Gopa Iyer; David B Solit; Zsofia K Stadler; Liying Zhang; Jonathan E Rosenberg; Barry S Taylor; Mark E Robson; Michael F Berger; Joseph Vijai; Dean F Bajorin; Kenneth Offit Journal: J Clin Oncol Date: 2019-12-03 Impact factor: 44.544