Literature DB >> 11696419

Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation.

Q Chen1, H Yoshida, D Schubert, P Maher, M Mallory, E Masliah.   

Abstract

A novel presenilin binding protein, PBP, has recently been identified. PBP is localized to the particulate fraction of extracts of Alzheimer's disease brain but is found in the soluble fractions of brain from age matched normal controls. It is shown here that PBP is associated with neurofibrillary tangles in Alzheimer's disease brain. In addition, the expression of PBP increases the phosphorylation of tau in cultured cells. Therefore PBP may have a regulatory role in tau phosphorylation and in the genesis of neurofibrillary tangles.

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Year:  2001        PMID： 11696419      PMCID： PMC1867048          DOI： 10.1016/S0002-9440(10)63005-2

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  39 in total

1.  THE FINE STRUCTURE OF NEUROFIBRILLARY TANGLES IN ALZHEIMER'S DISEASE.

Authors:  R D TERRY
Journal:  J Neuropathol Exp Neurol       Date:  1963-10       Impact factor: 3.685

2.  ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA.

Authors:  R D TERRY; N K GONATAS; M WEISS
Journal:  Am J Pathol       Date:  1964-02       Impact factor: 4.307

3.  Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

Authors:  M Hong; V Zhukareva; V Vogelsberg-Ragaglia; Z Wszolek; L Reed; B I Miller; D H Geschwind; T D Bird; D McKeel; A Goate; J C Morris; K C Wilhelmsen; G D Schellenberg; J Q Trojanowski; V M Lee
Journal:  Science       Date:  1998-12-04       Impact factor: 47.728

4.  FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10.

Authors:  M Hasegawa; M J Smith; M Iijima; T Tabira; M Goedert
Journal:  FEBS Lett       Date:  1999-01-25       Impact factor: 4.124

5.  Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig.

Authors:  D H Smith; X H Chen; M Nonaka; J Q Trojanowski; V M Lee; K E Saatman; M J Leoni; B N Xu; J A Wolf; D F Meaney
Journal:  J Neuropathol Exp Neurol       Date:  1999-09       Impact factor: 3.685

6.  Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly.

Authors:  M Hasegawa; M J Smith; M Goedert
Journal:  FEBS Lett       Date:  1998-10-23       Impact factor: 4.124

7.  beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

Authors:  J Busciglio; A Lorenzo; J Yeh; B A Yankner
Journal:  Neuron       Date:  1995-04       Impact factor: 17.173

8.  Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau.

Authors:  A Takashima; M Murayama; O Murayama; T Kohno; T Honda; K Yasutake; N Nihonmatsu; M Mercken; H Yamaguchi; S Sugihara; B Wolozin
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-04       Impact factor: 11.205

9.  Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17.

Authors:  L N Clark; P Poorkaj; Z Wszolek; D H Geschwind; Z S Nasreddine; B Miller; D Li; H Payami; F Awert; K Markopoulou; A Andreadis; I D'Souza; V M Lee; L Reed; J Q Trojanowski; V Zhukareva; T Bird; G Schellenberg; K C Wilhelmsen
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-27       Impact factor: 11.205

Review 10.  Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias.

Authors:  J Q Trojanowski; M L Schmidt; R W Shin; G T Bramblett; D Rao; V M Lee
Journal:  Brain Pathol       Date:  1993-01       Impact factor: 6.508
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  15 in total

1.  Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models.

Authors:  Jie Li; Xiujuan Mi; Ling Chen; Guohui Jiang; Na Wang; Yujiao Zhang; Wanni Deng; Zhihua Wang; Guojun Chen; Xuefeng Wang
Journal:  Mol Neurobiol       Date:  2015-08-30       Impact factor: 5.590

2.  The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics.

Authors:  Yangui Xiao; Yinghui Peng; Jun Wan; Genyun Tang; Yuewen Chen; Jing Tang; Wen-Cai Ye; Nancy Y Ip; Lei Shi
Journal:  J Biol Chem       Date:  2013-05-17       Impact factor: 5.157

3.  Variants in DOCK3 cause developmental delay and hypotonia.

Authors:  Kimberly Wiltrout; Alejandro Ferrer; Ingrid van de Laar; Kazuhiko Namekata; Takayuki Harada; Eric W Klee; Michael T Zimmerman; Margot A Cousin; Jennifer L Kempainen; Dusica Babovic-Vuksanovic; Marjon A van Slegtenhorst; Coranne D Aarts-Tesselaar; Rhonda E Schnur; Marisa Andrews; Marwan Shinawi
Journal:  Eur J Hum Genet       Date:  2019-04-11       Impact factor: 4.246

Review 4.  Reversing synapse loss in Alzheimer's disease: Rho-guanosine triphosphatases and insights from other brain disorders.

Authors:  Roger Lefort
Journal:  Neurotherapeutics       Date:  2015-01       Impact factor: 7.620

5.  DOCK3-related neurodevelopmental syndrome: Biallelic intragenic deletion of DOCK3 in a boy with developmental delay and hypotonia.

Authors:  Aiko Iwata-Otsubo; Alyssa L Ritter; Brooke Weckselbatt; Nicole R Ryan; David Burgess; Laura K Conlin; Kosuke Izumi
Journal:  Am J Med Genet A       Date:  2017-11-12       Impact factor: 2.802

6.  Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma.

Authors:  K Namekata; A Kimura; K Kawamura; X Guo; C Harada; K Tanaka; T Harada
Journal:  Cell Death Differ       Date:  2013-07-12       Impact factor: 15.828

7.  Modifier of cell adhesion regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth.

Authors:  Qi Chen; Tsan-Ju Chen; Paul C Letourneau; Luciano Da F Costa; David Schubert
Journal:  J Neurosci       Date:  2005-01-12       Impact factor: 6.167

8.  Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype.

Authors:  M G de Silva; K Elliott; H-H Dahl; E Fitzpatrick; S Wilcox; M Delatycki; R Williamson; D Efron; M Lynch; S Forrest
Journal:  J Med Genet       Date:  2003-10       Impact factor: 6.318

9.  Loss of modifier of cell adhesion reveals a pathway leading to axonal degeneration.

Authors:  Qi Chen; Charles A Peto; G Diane Shelton; Andrew Mizisin; Paul E Sawchenko; David Schubert
Journal:  J Neurosci       Date:  2009-01-07       Impact factor: 6.167

10.  Dock3 interaction with a glutamate-receptor NR2D subunit protects neurons from excitotoxicity.

Authors:  Ning Bai; Hideki Hayashi; Tomomi Aida; Kazuhiko Namekata; Takayuki Harada; Masayoshi Mishina; Kohichi Tanaka
Journal:  Mol Brain       Date:  2013-05-04       Impact factor: 4.041
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