AIMS: Coagulase-negative staphylococci (CNS) are now important nosocomial pathogens and are usually resistant to multiple antibiotics. Citrate is an alternative antimicrobial product which has been used as a preservative. METHODS AND RESULTS: In this pilot study the bactericidal activity of Na citrate against 10 isolates of CNS and 6 other gram-positive pathogens was examined and compared with that of Na lactate. CONCLUSIONS: All staphylococci tested were susceptible (> or = 2 log(10) killing) to citrate at 6.25-25 mg ml(-1). Na lactate showed only modest killing at 50 or 100 mg ml(-1). SIGNIFICANCE AND IMPACT OF THE STUDY: Citrate may warrant broader evaluation as an antimicrobial additive such as in topical agents.
AIMS: Coagulase-negative staphylococci (CNS) are now important nosocomial pathogens and are usually resistant to multiple antibiotics. Citrate is an alternative antimicrobial product which has been used as a preservative. METHODS AND RESULTS: In this pilot study the bactericidal activity of Na citrate against 10 isolates of CNS and 6 other gram-positive pathogens was examined and compared with that of Na lactate. CONCLUSIONS: All staphylococci tested were susceptible (> or = 2 log(10) killing) to citrate at 6.25-25 mg ml(-1). Na lactate showed only modest killing at 50 or 100 mg ml(-1). SIGNIFICANCE AND IMPACT OF THE STUDY: Citrate may warrant broader evaluation as an antimicrobial additive such as in topical agents.
Authors: Stefan Riedel; Alan Junkins; Paul D Stamper; Gretchen Cress; John A Widness; Gary V Doern Journal: J Clin Microbiol Date: 2009-04-15 Impact factor: 5.948
Authors: Robert M Q Shanks; Michael A Meehl; Kimberly M Brothers; Raquel M Martinez; Niles P Donegan; Martha L Graber; Ambrose L Cheung; George A O'Toole Journal: Infect Immun Date: 2008-03-17 Impact factor: 3.441