L Dahlgren1, R D Wilson. 1. University of British Columbia Division of Maternal Fetal Medicine, B.C. Women's Hospital, Vancouver, B.C., Canada.
Abstract
OBJECTIVE: To determine the incidence and etiology of prenatally diagnosed microcephaly. METHODS: Retrospective review of 10 years at a tertiary obstetrical hospital. The study population consisted of 21 infants with confirmed prenatal and postnatal microcephaly. RESULTS: There were 8 different definite/probable etiologies identified (viral, monochorionic twinning, genetic syndrome, neural tube defect, abnormal karyotype, hypoxic insult, constitutional). CONCLUSIONS: Retrospective study indicates the commonest etiologies for prenatal microcephaly are in utero infection, monochorionic twin insult, rare genetic syndrome and chromosomal anomalies. Copyright 2001 S. Karger AG, Basel
OBJECTIVE: To determine the incidence and etiology of prenatally diagnosed microcephaly. METHODS: Retrospective review of 10 years at a tertiary obstetrical hospital. The study population consisted of 21 infants with confirmed prenatal and postnatal microcephaly. RESULTS: There were 8 different definite/probable etiologies identified (viral, monochorionic twinning, genetic syndrome, neural tube defect, abnormal karyotype, hypoxic insult, constitutional). CONCLUSIONS: Retrospective study indicates the commonest etiologies for prenatal microcephaly are in utero infection, monochorionic twin insult, rare genetic syndrome and chromosomal anomalies. Copyright 2001 S. Karger AG, Basel