Literature DB >> 11692148

Relationship between apoptosis regulator proteins (bcl-2 and p53) and Gleason score in prostate cancer.

S Karaburun Paker1, B Kilicarslan, A M Ciftcioglu, S Oztekin, F C Sargin, T Erdogru, M Baykara.   

Abstract

Cellular proliferation programmed cell death (apoptosis) are associated with tumor growth in general, and prostate cancer growth in particular. The aim of this study was to examine the expression of the apoptosis regulating genes bcl-2 and p53 and Gleason score in core needle biopsy specimens of prostate cancer using immunohistochemistry. We studied bcl-2 and p53 expression in 12 cases of low grade (Gleason score 2-5), 12 cases of intermediate grade (Gleason score 6-7) and 8 cases of high grade (Gleason score 8-10) prostate cancer. Overexpression of bcl-2 was noted in 3 of 32 patients (9.32%). One of them was high grade; others were intermediate grades. Expression of p53 was observed in 3 of low grades; others were high grade. The statistical analysis of present data suggest that there is no significant relation between p53 and bcl-2 expression and Gleason score in prostate cancer.

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Year:  2001        PMID： 11692148     DOI： 10.1007/bf03032351

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  19 in total

1.  Locally recurrent prostate tumors following either radiation therapy or radical prostatectomy have changes in Ki-67 labeling index, p53 and bcl-2 immunoreactivity.

Authors:  G D Grossfeld; A F Olumi; J A Connolly; K Chew; J Gibney; V Bhargava; F M Waldman; P R Carroll
Journal:  J Urol       Date:  1998-05       Impact factor: 7.450

2.  Elevated levels of apoptosis regulator proteins p53 and bcl-2 are independent prognostic biomarkers in surgically treated clinically localized prostate cancer.

Authors:  J J Bauer; I A Sesterhenn; F K Mostofi; D G McLeod; S Srivastava; J W Moul
Journal:  J Urol       Date:  1996-10       Impact factor: 7.450

Review 3.  p53, the cellular gatekeeper for growth and division.

Authors:  A J Levine
Journal:  Cell       Date:  1997-02-07       Impact factor: 41.582

4.  Prognostic significance of Bcl-2 in clinically localized prostate cancer.

Authors:  L Bubendorf; G Sauter; H Moch; P Jordan; A Blöchlinger; T C Gasser; M J Mihatsch
Journal:  Am J Pathol       Date:  1996-05       Impact factor: 4.307

5.  p53 immunohistochemical and genetic alterations are associated at high incidence with post-irradiated locally persistent prostate carcinoma.

Authors:  N J Prendergast; M R Atkins; E C Schatte; D F Paulson; P J Walther
Journal:  J Urol       Date:  1996-05       Impact factor: 7.450

6.  p53 alteration in regional lymph node metastases from prostate carcinoma: a marker for progression?

Authors:  L Cheng; B C Leibovich; E J Bergstralh; B G Scherer; A Pacelli; D M Ramnani; H Zincke; D G Bostwick
Journal:  Cancer       Date:  1999-06-01       Impact factor: 6.860

7.  The biologic dilemma of early carcinoma of the prostate.

Authors:  A C von Eschenbach
Journal:  Cancer       Date:  1996-07-15       Impact factor: 6.860

8.  Combined analysis with Bcl-2 and P53 immunostaining predicts poorer prognosis in prostatic carcinoma.

Authors:  H Matsushima; T Kitamura; T Goto; Y Hosaka; Y Homma; K Kawabe
Journal:  J Urol       Date:  1997-12       Impact factor: 7.450

Review 9.  College of American Pathologists Conference XXVI on clinical relevance of prognostic markers in solid tumors. Report of the Prostate Cancer Working Group.

Authors:  D J Grignon; E H Hammond
Journal:  Arch Pathol Lab Med       Date:  1995-12       Impact factor: 5.534

10.  p53 and bcl-2 expression in high-grade B-cell lymphomas: correlation with survival time.

Authors:  M A Piris; F Pezzella; J C Martinez-Montero; J L Orradre; R Villuendas; M Sanchez-Beato; R Cuena; M A Cruz; B Martinez; F ] Pezella F [corrected to Pezzella
Journal:  Br J Cancer       Date:  1994-02       Impact factor: 7.640
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  2 in total

1.  The effects of melatonin and the antioxidant defence system on apoptosis regulator proteins (Bax and Bcl-2) in experimentally induced varicocele.

Authors:  R Onur; A Semerciöz; I Orhan; H Yekeler
Journal:  Urol Res       Date:  2004-02-06

2.  Role of cyclin D1 immunoreactivity and AgNOR staining in the evaluation of benign and malignant lesions of the prostate.

Authors:  Veena Gupta; Monika Garg; Manish Chaudhry; Sunita Singh; Rajeev Sen; Meenu Gill; Ashok Sangwaiya
Journal:  Prostate Int       Date:  2014-06-30
  2 in total

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