BACKGROUND: Even though atopic sensitization has been shown to be strongly associated with childhood asthma, asthma eventually develops in only one third of atopic children. OBJECTIVE: The aim of this study was to prospectively investigate the pattern of atopic sensitization typically associated with the development of asthma in childhood. METHODS: The German Multicenter Allergy Study followed 1314 children from birth to the age of 7 years. Parental questionnaires on asthma and asthmatic symptoms were completed 6 times up to the age of 2 years and from then on yearly. Determination of specific IgE to 9 food and inhalant allergens was performed yearly, and at the age of 7 years, a bronchial histamine challenge was conducted. RESULTS: Onset of atopic sensitization in atopic children with current asthma at the age of 7 years was significantly earlier than in atopic children without current asthma (39.4% before age 1 year vs 21.0%, P =.015). Early atopic sensitization without any sensitization to inhalant allergens at the age of 7 years conferred no increased risk for asthma at this age. Only those children sensitized to any allergen early in life and sensitized to inhalant allergens by the age of 7 years were at a significantly increased risk of being asthmatic at this age (odds ratio, 10.12; 95% CI, 3.81-26.88). However, even in this group of persistently sensitized children, the risk of being asthmatic at the age of 7 years was only increased if a positive parental history of asthma or atopy was present (odds ratio, 15.56; 95% CI, 5.78-41.83), with the effect being strongest for maternal asthma. CONCLUSION: Our results indicate that an underlying factor pertaining to asthma and maternal transmission may determine both a certain pattern of sensitization and the expression of asthma.
BACKGROUND: Even though atopic sensitization has been shown to be strongly associated with childhood asthma, asthma eventually develops in only one third of atopic children. OBJECTIVE: The aim of this study was to prospectively investigate the pattern of atopic sensitization typically associated with the development of asthma in childhood. METHODS: The German Multicenter Allergy Study followed 1314 children from birth to the age of 7 years. Parental questionnaires on asthma and asthmatic symptoms were completed 6 times up to the age of 2 years and from then on yearly. Determination of specific IgE to 9 food and inhalant allergens was performed yearly, and at the age of 7 years, a bronchial histamine challenge was conducted. RESULTS: Onset of atopic sensitization in atopic children with current asthma at the age of 7 years was significantly earlier than in atopic children without current asthma (39.4% before age 1 year vs 21.0%, P =.015). Early atopic sensitization without any sensitization to inhalant allergens at the age of 7 years conferred no increased risk for asthma at this age. Only those children sensitized to any allergen early in life and sensitized to inhalant allergens by the age of 7 years were at a significantly increased risk of being asthmatic at this age (odds ratio, 10.12; 95% CI, 3.81-26.88). However, even in this group of persistently sensitized children, the risk of being asthmatic at the age of 7 years was only increased if a positive parental history of asthma or atopy was present (odds ratio, 15.56; 95% CI, 5.78-41.83), with the effect being strongest for maternal asthma. CONCLUSION: Our results indicate that an underlying factor pertaining to asthma and maternal transmission may determine both a certain pattern of sensitization and the expression of asthma.
Authors: Akshay Sood; Clifford Qualls; Mark Schuyler; Bharat Thyagarajan; Michael W Steffes; Lewis J Smith; David R Jacobs Journal: Am J Respir Crit Care Med Date: 2012-04-06 Impact factor: 21.405
Authors: Daniel Chang; Weiguo Yao; Christina J Tiller; Jeffrey Kisling; James E Slaven; Zhangsheng Yu; Mark H Kaplan; Robert S Tepper Journal: Eur Respir J Date: 2014-09-26 Impact factor: 16.671
Authors: Vincent Lombardi; Philippe Stock; Abinav K Singh; Jerome Kerzerho; Wen Yang; Barbara A Sullivan; Xiangming Li; Takayuki Shiratsuchi; Nathan E Hnatiuk; Amy R Howell; Karl O A Yu; Steven A Porcelli; Moriya Tsuji; Mitchell Kronenberg; S Brian Wilson; Omid Akbari Journal: J Immunol Date: 2010-01-18 Impact factor: 5.422
Authors: Ben D Spycher; Michael Silverman; Juerg Barben; Ernst Eber; Stéphane Guinand; Mark L Levy; Caroline Pao; Willem M van Aalderen; Onno C P van Schayck; Claudia E Kuehni Journal: PLoS One Date: 2009-12-31 Impact factor: 3.240