Literature DB >> 11691702

Shortened duration of untreated first episode of psychosis: changes in patient characteristics at treatment.

T K Larsen1, T H McGlashan, J O Johannessen, S Friis, C Guldberg, U Haahr, M Horneland, I Melle, L C Moe, S Opjordsmoen, E Simonsen, P Vaglum.   

Abstract

OBJECTIVE: This study examined whether duration of untreated psychosis can be shortened in patients with first episodes of DSM-IV schizophrenia spectrum disorders and whether shorted duration alters patient appearance at treatment.
METHOD: Two study groups were ascertained in the same Norwegian health care sector: one from 1993-1994 with usual detection methods and one from 1997-1998 with early detection strategies that included education about psychosis.
RESULTS: Patients with early detection had a shorter median duration of untreated psychosis by 21.5 weeks than patients with usual detection. The number with psychosis was greater in the early detection group; the number with schizophrenia was less. Early detection patients had more substance abuse and were younger, better adjusted premorbidly, and less ill.
CONCLUSIONS: Early detection can shorten duration of untreated psychosis and help more patients when they are less severely ill. Given the devastation of psychosis, this is a significant treatment advance.

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Year:  2001        PMID: 11691702     DOI: 10.1176/appi.ajp.158.11.1917

Source DB:  PubMed          Journal:  Am J Psychiatry        ISSN: 0002-953X            Impact factor:   18.112


  27 in total

Review 1.  Clinical staging in the pathophysiology of psychotic and affective disorders: facilitation of prognosis and treatment.

Authors:  Trevor Archer; Richard M Kostrzewa; Tomas Palomo; Richard J Beninger
Journal:  Neurotox Res       Date:  2010-03-17       Impact factor: 3.911

2.  Early intervention in first-episode psychosis--the impact of a community development campaign.

Authors:  Helen Krstev; Steve Carbone; Susy M Harrigan; Christina Curry; Kathryn Elkins; Patrick D McGorry
Journal:  Soc Psychiatry Psychiatr Epidemiol       Date:  2004-09       Impact factor: 4.328

3.  Reducing the duration of untreated psychosis and changing help-seeking behaviour in Singapore.

Authors:  Siow-Ann Chong; S Mythily; Swapna Verma
Journal:  Soc Psychiatry Psychiatr Epidemiol       Date:  2005-08-16       Impact factor: 4.328

4.  The key to reducing duration of untreated first psychosis: information campaigns.

Authors:  Inge Joa; Jan Olav Johannessen; Bjørn Auestad; Svein Friis; Thomas McGlashan; Ingrid Melle; Stein Opjordsmoen; Erik Simonsen; Per Vaglum; Tor K Larsen
Journal:  Schizophr Bull       Date:  2007-09-28       Impact factor: 9.306

5.  The Effect of Substance Use on 10-Year Outcome in First-Episode Psychosis.

Authors:  Melissa A Weibell; Wenche Ten Velden Hegelstad; Bjørn Auestad; Jørgen Bramness; Julie Evensen; Ulrik Haahr; Inge Joa; Jan Olav Johannessen; Tor Ketil Larsen; Ingrid Melle; Stein Opjordsmoen; Bjørn Rishovd Rund; Erik Simonsen; Per Vaglum; Thomas McGlashan; Patrick McGorry; Svein Friis
Journal:  Schizophr Bull       Date:  2017-07-01       Impact factor: 9.306

Review 6.  Preventing the second episode: a systematic review and meta-analysis of psychosocial and pharmacological trials in first-episode psychosis.

Authors:  Mario Alvarez-Jiménez; Alexandra G Parker; Sarah E Hetrick; Patrick D McGorry; John F Gleeson
Journal:  Schizophr Bull       Date:  2009-11-09       Impact factor: 9.306

7.  Contrasting monosymptomatic patients with hallucinations and delusions in first-episode psychosis patients: a five-year longitudinal follow-up study.

Authors:  Julie Evensen; Jan Ivar Røssberg; Ulrik Haahr; Wenche ten Velden Hegelstad; Inge Joa; Jan Olav Johannessen; Hans Langeveld; T K Larsen; Ingrid Melle; Stein Opjordsmoen; Bjørn Rishovd Rund; Erik Simonsen; Kjetil Sundet; Per Vaglum; Svein Friis; Thomas McGlashan
Journal:  Psychopathology       Date:  2011-01-13       Impact factor: 1.944

8.  Treatment timing vs treatment type in first-episode psychosis: a paradigm shift in strategy and effectiveness.

Authors:  Thomas H McGlashan
Journal:  Schizophr Bull       Date:  2012-09       Impact factor: 9.306

9.  A controlled evaluation of a targeted early case detection intervention for reducing delay in treatment of first episode psychosis.

Authors:  Ashok Malla; Gerald Jordan; Ridha Joober; Norbert Schmitz; Ross Norman; Thomas Brown; Karen Goldberg; Heleen Loohuis; Nadia Vracotas; Joseph Rochford
Journal:  Soc Psychiatry Psychiatr Epidemiol       Date:  2014-06-06       Impact factor: 4.328

10.  Effects of duration of untreated psychosis on long-term outcome of people hospitalized with first episode schizophrenia.

Authors:  Amresh Shrivastava; Nilesh Shah; Megan Johnston; Larry Stitt; Meghana Thakar; Gurusamy Chinnasamy
Journal:  Indian J Psychiatry       Date:  2010-04       Impact factor: 1.759

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