Literature DB >> 11691576

Penicillin and clindamycin differentially inhibit the production of pyrogenic exotoxins A and B by group A streptococci.

E M Mascini1, M Jansze, L M Schouls, J Verhoef, H Van Dijk.   

Abstract

Streptococcal pyrogenic exotoxins A (SPE-A) and B (SPE-B) have been implicated in the pathogenesis of serious group A streptococcal infections including streptococcal toxic shock-syndrome. Current antibiotics used for the treatment of these infections are penicillin and clindamycin. The effects of sub- and suprainhibitory concentrations of penicillin and clindamycin were evaluated in 14 isolates of Streptococcus pyogenes that were fully susceptible to both antibiotics. Clindamycin was superior to penicillin in reducing the production of SPE-A and SPE-B by invasive and non-invasive Dutch group A streptococcal isolates in vitro.

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Year:  2001        PMID： 11691576     DOI： 10.1016/s0924-8579(01)00413-7

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  25 in total

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