Literature DB >> 11689671

Interleukin-4 up-regulates mouse mammary tumor virus expression yet is not required for in vivo virus spread.

J Czarneski1, J Meyers, T Peng, V Abraham, R Mick, S R Ross.   

Abstract

The mouse mammary tumor virus (MMTV) superantigen induces T-cell production of cytokines, such as interleukin-4, which in turn increase MMTV transcription. However, interleukin-4 is not required for in vivo virus spread, because mice lacking interleukin-4 or the STAT6 transcription factor showed wild-type infection of lymphoid and mammary tissue. In spite of this, mammary tumor incidence was decreased in STAT6 null mice.

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Year:  2001        PMID： 11689671      PMCID： PMC114776          DOI： 10.1128/JVI.75.23.11886-11890.2001

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  41 in total

Review 1.  The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense.

Authors:  L A O'Neill
Journal:  Sci STKE       Date:  2000-08-08

2.  Both stat5a and stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue.

Authors:  S i Kagami; H Nakajima; K Kumano; K Suzuki; A Suto; K Imada; H W Davey; Y Saito; K Takatsu; W J Leonard; I Iwamoto
Journal:  Blood       Date:  2000-02-15       Impact factor: 22.113

3.  Lipopolysaccharide and dexamethasone induce mouse mammary tumor proviral gene expression and differentiation in B lymphocytes through distinct regulatory pathways.

Authors:  L B King; R B Corley
Journal:  Mol Cell Biol       Date:  1990-08       Impact factor: 4.272

4.  Cutting edge: spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice.

Authors:  A K Kacha; F Fallarino; M A Markiewicz; T F Gajewski
Journal:  J Immunol       Date:  2000-12-01       Impact factor: 5.422

5.  Coexpression of exogenous and endogenous mouse mammary tumor virus RNA in vivo results in viral recombination and broadens the virus host range.

Authors:  T V Golovkina; A B Jaffe; S R Ross
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

6.  Mouse mammary tumor virus-induced tumorigenesis in sag transgenic mice: a laboratory model of natural selection.

Authors:  T V Golovkina; J A Prescott; S R Ross
Journal:  J Virol       Date:  1993-12       Impact factor: 5.103

7.  Mouse mammary tumor virus gene expression regulated in trans by Lps locus.

Authors:  J K Carr; V L Traina-Dorge; J C Cohen
Journal:  Virology       Date:  1985-11       Impact factor: 3.616

8.  The effects of chronic infection with a superantigen-producing virus.

Authors:  L Ignatowicz; J Kappler; P Marrack
Journal:  J Exp Med       Date:  1992-04-01       Impact factor: 14.307

9.  Superantigen-reactive CD4+ T cells are required to stimulate B cells after infection with mouse mammary tumor virus.

Authors:  W Held; A N Shakhov; S Izui; G A Waanders; L Scarpellino; H R MacDonald; H Acha-Orbea
Journal:  J Exp Med       Date:  1993-02-01       Impact factor: 14.307

10.  Peripheral T cell activation and deletion induced by transfer of lymphocyte subsets expressing endogenous or exogenous mouse mammary tumor virus.

Authors:  G A Waanders; A N Shakhov; W Held; O Karapetian; H Acha-Orbea; H R MacDonald
Journal:  J Exp Med       Date:  1993-05-01       Impact factor: 14.307
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  2 in total

Review 1.  MMTV infectious cycle and the contribution of virus-encoded proteins to transformation of mammary tissue.

Authors:  Susan R Ross
Journal:  J Mammary Gland Biol Neoplasia       Date:  2008-07-26       Impact factor: 2.673

2.  Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Authors:  Vicki Plaks; Bijan Boldajipour; Jelena R Linnemann; Nguyen H Nguyen; Kelly Kersten; Yochai Wolf; Amy-Jo Casbon; Niwen Kong; Renske J E van den Bijgaart; Dean Sheppard; Andrew C Melton; Matthew F Krummel; Zena Werb
Journal:  Dev Cell       Date:  2015-08-27       Impact factor: 12.270
  2 in total

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