| Literature DB >> 11689668 |
T Nakaya1, J Cros, M S Park, Y Nakaya, H Zheng, A Sagrera, E Villar, A García-Sastre, P Palese.
Abstract
A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the potential of recombinant NDV as a vaccine vector.Entities:
Mesh:
Substances:
Year: 2001 PMID: 11689668 PMCID: PMC114773 DOI: 10.1128/JVI.75.23.11868-11873.2001
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103