Neuromodulatory effects of serotonin antibodies on behavioral responses, neurotransmitter content in the central nervous system, and ligand-binding activity of central serotonin receptors in C57BL/6 and BALB/c mice.

Effects of active immunization with the serotonin-protein conjugate on open-field behavior, learning and retention of the conditioned passive avoidance response, neurotransmitter contents in brain structures, and functional activity of central serotonin receptors were studied on C57Bl/6 and BALB/c mice. Serotonin antibodies produced opposite effects on the studied parameters in genetically different mouse strains.