Literature DB >> 1168545

Alpha-amanitin resistance: a dominant mutation in CHO cells.

P E Lobban, L Siminovitch.   

Abstract

Hybrids of CHO cells were constructed consisting of either a 1:1 or 1:2 ratio of alpha-amanitin-resistant and sensitive cells, respectively. The resistance of such hybrids to killing by the drug was similar but slightly less than that of the resistant parent. The hybrids contained both resistant and wild-type RNA polymerase II, in amounts related to the expected gene dosage. The alpha-amanitin marker therefore is expressed codominantly.

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Year:  1975        PMID： 1168545     DOI： 10.1016/0092-8674(75)90123-3

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  8 in total

1.  Transfer of codominant markers by isolated metaphase chromosomes in Chinese hamster ovary cells.

Authors:  D A Spandidos; L Siminovitch
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

2.  Temperature-sensitive RNA polymerase II mutations in Chinese hamster ovary cells.

Authors:  C J Ingles
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

3.  Localization of an alpha-amanitin resistance mutation in the gene encoding the largest subunit of mouse RNA polymerase II.

Authors:  M S Bartolomei; J L Corden
Journal:  Mol Cell Biol       Date:  1987-02       Impact factor: 4.272

4.  Genetic characterization of methotrexate-resistant chinese hamster ovary cells.

Authors:  W F Flintoff; S M Spindler; L Siminovitch
Journal:  In Vitro       Date:  1976-11

5.  Restriction of herpes simplex virus by Ama 1 cells. An analysis of viral macromolecule synthesis.

Authors:  G Campadelli-Fiume; F Costanzo; L Foa'-Tomasi
Journal:  Arch Virol       Date:  1980       Impact factor: 2.574

6.  Myogenic differentiation of L6 rat myoblasts: evidence for pleiotropic effects on myogenesis by RNA polymerase II mutations to alpha-amanitin resistance.

Authors:  M M Crerar; R Leather; E David; M L Pearson
Journal:  Mol Cell Biol       Date:  1983-05       Impact factor: 4.272

7.  A method for assaying DNA-dependent RNA polymerase II in crude extracts of Drosophila melanogaster adults: its use in identifying mutants with an altered RNA polymerase II.

Authors:  J T Nishiura
Journal:  Biochem Genet       Date:  1981-02       Impact factor: 1.890

8.  Synthesis of influenza virus polypeptides in cells resistant to alpha-amanitin: evidence for the involvement of cellular RNA polymerase II in virus replication.

Authors:  R A Lamb; P W Choppin
Journal:  J Virol       Date:  1977-09       Impact factor: 5.103
  8 in total

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