Literature DB >> 11685373

Structure and localization of cyclosporin synthetase, the key enzyme of cyclosporin biosynthesis in Tolypocladium inflatum.

M Hoppert1, C Gentzsch, K Schörgendorfer.   

Abstract

The electron microscopic image of native cyclosporin synthetase molecules showed large globular complexes of 25 nm in diameter, built up by smaller interconnected units. Compartmentation of cyclosporin synthetase and the functionally interconnected D-alanine racemase was revealed after sucrose density gradient centrifugation of subcellular fractions and immunoelectron microscopy. A considerable proportion of cyclosporin synthetase and D-alanine racemase was detected at the vacuolar membrane. The product cyclosporin was localized in the fungal vacuole.

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Year:  2001        PMID： 11685373     DOI： 10.1007/s002030100324

Source DB:  PubMed          Journal:  Arch Microbiol        ISSN： 0302-8933            Impact factor:   2.552


  13 in total

Review 1.  Spatial and temporal control of fungal natural product synthesis.

Authors:  Fang Yun Lim; Nancy P Keller
Journal:  Nat Prod Rep       Date:  2014-10       Impact factor: 13.423

Review 2.  Biosynthesis of depsipeptides, or Depsi: The peptides with varied generations.

Authors:  Diego A Alonzo; T Martin Schmeing
Journal:  Protein Sci       Date:  2020-11-02       Impact factor: 6.725

3.  Two novel classes of enzymes are required for the biosynthesis of aurofusarin in Fusarium graminearum.

Authors:  Rasmus J N Frandsen; Claes Schütt; Birgitte W Lund; Dan Staerk; John Nielsen; Stefan Olsson; Henriette Giese
Journal:  J Biol Chem       Date:  2011-02-04       Impact factor: 5.157

Review 4.  Compartmentalization and molecular traffic in secondary metabolism: a new understanding of established cellular processes.

Authors:  Ludmila V Roze; Anindya Chanda; John E Linz
Journal:  Fungal Genet Biol       Date:  2010-05-16       Impact factor: 3.495

5.  Rhizonin, the first mycotoxin isolated from the zygomycota, is not a fungal metabolite but is produced by bacterial endosymbionts.

Authors:  Laila P Partida-Martinez; Carina Flores de Looss; Keishi Ishida; Mie Ishida; Martin Roth; Katrin Buder; Christian Hertweck
Journal:  Appl Environ Microbiol       Date:  2006-11-22       Impact factor: 4.792

6.  A key role for vesicles in fungal secondary metabolism.

Authors:  Anindya Chanda; Ludmila V Roze; Suil Kang; Katherine A Artymovich; Glenn R Hicks; Natasha V Raikhel; Ana M Calvo; John E Linz
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-04       Impact factor: 11.205

7.  Subcellular Compartmentalization and Trafficking of the Biosynthetic Machinery for Fungal Melanin.

Authors:  Srijana Upadhyay; Xinping Xu; David Lowry; Jennifer C Jackson; Robert W Roberson; Xiaorong Lin
Journal:  Cell Rep       Date:  2016-03-10       Impact factor: 9.423

8.  Purification of a vesicle-vacuole fraction functionally linked to aflatoxin synthesis in Aspergillus parasiticus.

Authors:  Anindya Chanda; Ludmila V Roze; Alicia Pastor; Melinda K Frame; John E Linz
Journal:  J Microbiol Methods       Date:  2009-04-07       Impact factor: 2.363

9.  In vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coli.

Authors:  Stephan Gruenewald; Henning D Mootz; Per Stehmeier; Torsten Stachelhaus
Journal:  Appl Environ Microbiol       Date:  2004-06       Impact factor: 4.792

Review 10.  The inherent flexibility of type I non-ribosomal peptide synthetase multienzymes drives their catalytic activities.

Authors:  Sarah Bonhomme; Andréa Dessen; Pauline Macheboeuf
Journal:  Open Biol       Date:  2021-05-26       Impact factor: 6.411
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