| Literature DB >> 11684884 |
P Bang1, M Ahlsén, U Berg, C Carlsson-Skwirut.
Abstract
During the last decade, there has been an increasing number of publications reporting concentrations of free dissociable insulin-like growth factor I (IGF-I) in serum or plasma. The goal for attempting to measure free IGF-I in a serum sample in vitro has been to obtain information about the bioactivity of IGF-I in target tissues, and thus relate a measurable parameter to biological responses such as longitudinal growth or glucose disappearance rate. In this review, the serum free IGF-I approach is placed into a physiological perspective. In addition, methodological aspects are discussed and suggestions for the validation of free IGF-I assays are presented. Copyright 2001 S. Karger AG, BaselEntities:
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Year: 2001 PMID: 11684884 DOI: 10.1159/000063482
Source DB: PubMed Journal: Horm Res ISSN: 0301-0163