T C Chang1, W L Chen, W P Chang, C J Chen. 1. Department of Internal Medicine, College of Medicine and National Taiwan University Hospital, National Taiwan University, 7 Chung-Shan South Road, Taipei 100, Taiwan. tcchang1@ms10.hinet.net
Abstract
PURPOSE: To evaluate prolonged low dose-rate gamma-exposure effects on the thyroid glands of residents living in 60Co-contaminated steel buildings. MATERIALS AND METHODS: Physical examination and ultrasonography of the thyroid, determination of thyroid function and anti-thyroid microsomal antibodies were performed for 1346 residents. Ultrasound-guided aspiration cytology was done for thyroid nodules. The study subjects were stratified by age at examination (< or = 15 and > 15 years), sex and exposure dose to the body. Dose-response data on the prevalence of various thyroid diseases were analysed by the multiple logistic regression analysis. RESULTS AND CONCLUSIONS: The prevalence of simple goitre was related to the exposure with a dose-response relationship for males of all ages, and for females of < or = 15 years. There was a biological gradient of thyroid cyst prevalence with the increase in exposure dose for females of all ages. The prevalence of elevated serum tri-iodothyronine level showed a dose-response relationship for males of < or = 15 years. A significant increase in thyroid abnormalities with dose was observed for males of all ages, and for females of < or = 15 years.
PURPOSE: To evaluate prolonged low dose-rate gamma-exposure effects on the thyroid glands of residents living in 60Co-contaminated steel buildings. MATERIALS AND METHODS: Physical examination and ultrasonography of the thyroid, determination of thyroid function and anti-thyroid microsomal antibodies were performed for 1346 residents. Ultrasound-guided aspiration cytology was done for thyroid nodules. The study subjects were stratified by age at examination (< or = 15 and > 15 years), sex and exposure dose to the body. Dose-response data on the prevalence of various thyroid diseases were analysed by the multiple logistic regression analysis. RESULTS AND CONCLUSIONS: The prevalence of simple goitre was related to the exposure with a dose-response relationship for males of all ages, and for females of < or = 15 years. There was a biological gradient of thyroid cyst prevalence with the increase in exposure dose for females of all ages. The prevalence of elevated serum tri-iodothyronine level showed a dose-response relationship for males of < or = 15 years. A significant increase in thyroid abnormalities with dose was observed for males of all ages, and for females of < or = 15 years.
Authors: Yun-Keun Lee; Young-Su Ju; Won Jin Lee; Seung Sik Hwang; Sang-Hyuk Yim; Sang-Chul Yoo; Jieon Lee; Kyung-Hwa Choi; Eunae Burm; Mina Ha Journal: Environ Health Toxicol Date: 2015-06-29
Authors: Mina Ha; Young Su Ju; Won Jin Lee; Seung Sik Hwang; Sang Chul Yoo; Kyung Hwa Choi; Eunae Burm; Jieon Lee; Yun Keun Lee; Sanghyuk Im Journal: J Korean Med Sci Date: 2018-02-26 Impact factor: 2.153