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Literature DB >> 11682245

Role of dopamine D(4) receptors in motor hyperactivity induced by neonatal 6-hydroxydopamine lesions in rats.

Abstract

The role of dopamine D(4) receptors in behavioral hyperactivity was investigated by assessing D(4) receptor expression in brain regions and behavioral effects of D(4) receptor-selective ligands in juvenile rats with neonatal 6-hydroxydopamine lesions, a laboratory model for attention deficit-hyperactivity disorder (ADHD). Autoradiographic analysis indicated that motor hyperactivity in lesioned rats was closely correlated with increases in D(4) but not D(2) receptor levels in caudate-putamen. D(4)-selective antagonist CP-293,019 dose-dependently reversed lesion-induced hyperactivity, and D(4)-agonist CP-226,269 increased it. These results indicate a physiological role of dopamine D(4) receptors in motor behavior, and may suggest much-needed innovative treatments for ADHD.

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Year: 2001 PMID： 11682245 DOI： 10.1016/S0893-133X(01)00262-7

Source DB: PubMed Journal: Neuropsychopharmacology ISSN： 0893-133X Impact factor: 7.853

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Cited

16 in total

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2. Neuropharmacology of dopamine receptors:: Implications in neuropsychiatric diseases.

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3. D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD.

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Journal: Neurobiol Dis Date: 2009-10-22 Impact factor: 5.996

4. Pitx3-deficient aphakia mice display unique behavioral responses to psychostimulant and antipsychotic drugs.

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Journal: Neuroscience Date: 2009-12-22 Impact factor: 3.590

Review 5. Review of rodent models of attention deficit hyperactivity disorder.

Authors: Samantha L Regan; Michael T Williams; Charles V Vorhees
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Review 6. Pharmacological models of ADHD.

Authors: R M Kostrzewa; J P Kostrzewa; R A Kostrzewa; P Nowak; R Brus
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7. Decreased dopamine D4 receptor expression increases extracellular glutamate and alters its regulation in mouse striatum.

Authors: Theresa Currier Thomas; David K Grandy; Greg A Gerhardt; Paul E A Glaser
Journal: Neuropsychopharmacology Date: 2008-06-04 Impact factor: 7.853